Microparticles as biomarkers of vascular dysfunction in metabolic syndrome and its individual components
Agouni, A, Andriantsitohaina, R and Martinez, MC (2014) Microparticles as biomarkers of vascular dysfunction in metabolic syndrome and its individual components Current Vascular Pharmacology, 12 (3). pp. 483-492.
Agouni et al MPs review 2013.pdf
Heterogeneous in size (0.1-1 µm), microparticles are small membrane vesicles released from activated and/or apoptotic cells. Although described since 1967 by Wolf , it is only since the 1990’s that microparticles have been considered as biomarkers as well as potential mediators of biological messages between cells  by acting as paracrine and endocrine vectors. Detection of microparticles has been performed in biological fluids (blood, synovial fluid, saliva for instance) and some solid tissues but also from the culture medium . Levels of circulating microparticles are enhanced in a large number of pathological states including cardiovascular and metabolic disorders associated with insulin resistance and this has been linked to deleterious effects on cells from the vascular wall, mainly, endothelial cells. This review highlights the increasing impact of microparticles in major cardiovascular pathological situations associated with metabolic derangements.
|Divisions :||Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Biochemical Sciences|
|Date :||15 May 2014|
|Identification Number :||10.2174/1570161112666140423223148|
|Additional Information :||The published manuscript is available at http://dx.doi.org/10.2174/1570161112666140423223148|
|Depositing User :||Symplectic Elements|
|Date Deposited :||02 Dec 2015 18:34|
|Last Modified :||02 Dec 2015 18:35|
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