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The physiological period length of the human circadian clock in vivo is directly proportional to period in human fibroblasts.

Pagani, L, Semenova, EA, Moriggi, E, Revell, VL, Hack, LM, Lockley, SW, Arendt, J, Skene, DJ, Meier, F and Izakovic, J (2010) The physiological period length of the human circadian clock in vivo is directly proportional to period in human fibroblasts. PLoS One, 5 (10). e13376 - ?. ISSN 1932-6203

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Abstract

Diurnal behavior in humans is governed by the period length of a circadian clock in the suprachiasmatic nuclei of the brain hypothalamus. Nevertheless, the cell-intrinsic mechanism of this clock is present in most cells of the body. We have shown previously that for individuals of extreme chronotype ("larks" and "owls"), clock properties measured in human fibroblasts correlated with extreme diurnal behavior.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > Biochemistry and Physiology
Authors :
AuthorsEmail
Pagani, LUNSPECIFIED
Semenova, EAUNSPECIFIED
Moriggi, EUNSPECIFIED
Revell, VLUNSPECIFIED
Hack, LMUNSPECIFIED
Lockley, SWUNSPECIFIED
Arendt, JUNSPECIFIED
Skene, DJUNSPECIFIED
Meier, FUNSPECIFIED
Izakovic, JUNSPECIFIED
Date : 2010
Identification Number : 10.1371/journal.pone.0013376
Uncontrolled Keywords : Circadian Clocks, Fibroblasts, Humans
Additional Information : Copyright: © 2010 Pagani et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Depositing User : Symplectic Elements
Date Deposited : 02 Dec 2011 16:31
Last Modified : 23 Sep 2013 18:50
URI: http://epubs.surrey.ac.uk/id/eprint/7716

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