University of Surrey

Test tubes in the lab Research in the ATI Dance Research

The physiological period length of the human circadian clock in vivo is directly proportional to period in human fibroblasts.

Pagani, L, Semenova, EA, Moriggi, E, Revell, VL, Hack, LM, Lockley, SW, Arendt, J, Skene, DJ, Meier, F and Izakovic, J (2010) The physiological period length of the human circadian clock in vivo is directly proportional to period in human fibroblasts. PLoS One, 5 (10).

[img]
Preview
PDF
Pagani PLoS ONE.pdf - Version of Record

Download (919kB)

Abstract

Diurnal behavior in humans is governed by the period length of a circadian clock in the suprachiasmatic nuclei of the brain hypothalamus. Nevertheless, the cell-intrinsic mechanism of this clock is present in most cells of the body. We have shown previously that for individuals of extreme chronotype ("larks" and "owls"), clock properties measured in human fibroblasts correlated with extreme diurnal behavior.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Biochemical Sciences
Authors :
AuthorsEmailORCID
Pagani, LUNSPECIFIEDUNSPECIFIED
Semenova, EAUNSPECIFIEDUNSPECIFIED
Moriggi, EUNSPECIFIEDUNSPECIFIED
Revell, VLUNSPECIFIEDUNSPECIFIED
Hack, LMUNSPECIFIEDUNSPECIFIED
Lockley, SWUNSPECIFIEDUNSPECIFIED
Arendt, JUNSPECIFIEDUNSPECIFIED
Skene, DJUNSPECIFIEDUNSPECIFIED
Meier, FUNSPECIFIEDUNSPECIFIED
Izakovic, JUNSPECIFIEDUNSPECIFIED
Date : 2010
Identification Number : 10.1371/journal.pone.0013376
Uncontrolled Keywords : Circadian Clocks, Fibroblasts, Humans
Additional Information : Copyright: © 2010 Pagani et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Depositing User : Symplectic Elements
Date Deposited : 02 Dec 2011 16:31
Last Modified : 23 Sep 2013 18:50
URI: http://epubs.surrey.ac.uk/id/eprint/7716

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800