Aligned, isotropic and patterned carbon nanotube substrates that control the growth and alignment of Chinese hamster ovary cells.
Abdullah, CA, Asanithi, P, Brunner, EW, Jurewicz, I, Bo, C, Azad, CL, Ovalle-Robles, R, Fang, S, Lima, MD, Lepro, X , Collins, S, Baughman, RH, Sear, RP and Dalton, AB (2011) Aligned, isotropic and patterned carbon nanotube substrates that control the growth and alignment of Chinese hamster ovary cells. Nanotechnology, 22 (20).
![]()
|
Text
azura_nanotech2011.pdf Available under License : See the attached licence file. Download (3MB) |
|
![]() |
Text (licence)
licence.txt Download (1kB) |
Abstract
Here we culture Chinese hamster ovary cells on isotropic, aligned and patterned substrates based on multiwall carbon nanotubes. The nanotubes provide the substrate with nanoscale topography. The cells adhere to and grow on all substrates, and on the aligned substrate, the cells align strongly with the axis of the bundles of the multiwall nanotubes. This control over cell alignment is required for tissue engineering; almost all tissues consist of oriented cells. The aligned substrates are made using straightforward physical chemistry techniques from forests of multiwall nanotubes; no lithography is required to make inexpensive large-scale substrates with highly aligned nanoscale grooves. Interestingly, although the cells strongly align with the nanoscale grooves, only a few also elongate along this axis: alignment of the cells does not require a pronounced change in morphology of the cell. We also pattern the nanotube bundles over length scales comparable to the cell size and show that the cells follow this pattern.
Item Type: | Article | |||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Divisions : | Faculty of Engineering and Physical Sciences > Physics | |||||||||||||||||||||||||||||||||||||||||||||
Authors : |
|
|||||||||||||||||||||||||||||||||||||||||||||
Date : | 20 May 2011 | |||||||||||||||||||||||||||||||||||||||||||||
DOI : | 10.1088/0957-4484/22/20/205102 | |||||||||||||||||||||||||||||||||||||||||||||
Depositing User : | Symplectic Elements | |||||||||||||||||||||||||||||||||||||||||||||
Date Deposited : | 09 Nov 2011 10:54 | |||||||||||||||||||||||||||||||||||||||||||||
Last Modified : | 31 Oct 2017 14:11 | |||||||||||||||||||||||||||||||||||||||||||||
URI: | http://epubs.surrey.ac.uk/id/eprint/7606 |
Actions (login required)
![]() |
View Item |
Downloads
Downloads per month over past year