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Transparent micro- and nanopatterned poly(lactic acid) for biomedical applications.

Mills, CA, Navarro, M, Engel, E, Martinez, E, Ginebra, MP, Planell, J, Errachid, A and Samitier, J (2006) Transparent micro- and nanopatterned poly(lactic acid) for biomedical applications. Journal of Biomedical Materials Research Part A, 76 (4). pp. 781-787.

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Abstract

The formation of structures in poly(lactic acid) has been investigated with respect to producing areas of regular, superficial features with dimensions comparable to those of cells or biological macromolecules. Nanoembossing, a novel method of pattern replication in polymers, has been used for the production of features ranging from tens of micrometers, covering areas up to 1 cm(2), down to hundreds of nanometers. Both micro- and nanostructures are faithfully replicated. Contact-angle measurements suggest that positive microstructuring of the polymer (where features protrude from the polymer surface) produces a more hydrophilic surface than negative microstructuring. The ability to structure the surface of the poly(lactic acid), allied to the polymer's postprocessing transparency and proven biocompatibility, means that thin films produced in this way will be useful for bioengineers studying the interaction of micro- and nanodimensioned features with biological specimen, with regard to tissue engineering, for example.

Item Type: Article
Authors :
AuthorsEmailORCID
Mills, CAUNSPECIFIEDUNSPECIFIED
Navarro, MUNSPECIFIEDUNSPECIFIED
Engel, EUNSPECIFIEDUNSPECIFIED
Martinez, EUNSPECIFIEDUNSPECIFIED
Ginebra, MPUNSPECIFIEDUNSPECIFIED
Planell, JUNSPECIFIEDUNSPECIFIED
Errachid, AUNSPECIFIEDUNSPECIFIED
Samitier, JUNSPECIFIEDUNSPECIFIED
Date : 15 March 2006
Identification Number : https://doi.org/10.1002/jbm.a.30539
Uncontrolled Keywords : Biocompatible Materials, Cell Line, Lactic Acid, Nanotechnology, Polymers
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 28 Mar 2017 13:43
Last Modified : 28 Mar 2017 13:43
URI: http://epubs.surrey.ac.uk/id/eprint/755158

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