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Bioactivity and hemocompatibility study of amorphous hydrogenated carbon coatings produced by pulsed magnetron discharge.

Lopez-Santos, C, Colaux, JL, Laloy, J, Fransolet, M, Mullier, F, Michiels, C, Dogné, JM and Lucas, S (2013) Bioactivity and hemocompatibility study of amorphous hydrogenated carbon coatings produced by pulsed magnetron discharge. J Biomed Mater Res A, 101A (6). pp. 1800-1812.

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Abstract

Literature contains very few data about the potential biomedical application of amorphous hydrogenated carbon (a-C:H) thin films deposited by reactive pulsed magnetron discharge even so it is one of the most scalable plasma deposition technique. In this article, we show that such a C(2) H(2) pulsed magnetron plasma produces high quality coating with good hemocompatibility and bioactive response: no effect on hemolysis and hemostasis were observed, and proliferation of various cell types such as endothelial, fibroblast, and osteoblast-like cells was not affected when the deposition conditions were varied. Cell growth on a-C:H coatings is proposed to take place by a two-step process: the initial cell contact is affected by the smooth topography of the a-C:H coatings, whereas the polymeric-like structure, together with a moderate hydrophilicity and a high hydrogen content, directs the posterior cell spreading while preserving the hemocompatible behavior. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering > Advanced Technology Institute > Ion Beam Centre
Authors :
AuthorsEmailORCID
Lopez-Santos, CUNSPECIFIEDUNSPECIFIED
Colaux, JLUNSPECIFIEDUNSPECIFIED
Laloy, JUNSPECIFIEDUNSPECIFIED
Fransolet, MUNSPECIFIEDUNSPECIFIED
Mullier, FUNSPECIFIEDUNSPECIFIED
Michiels, CUNSPECIFIEDUNSPECIFIED
Dogné, JMUNSPECIFIEDUNSPECIFIED
Lucas, SUNSPECIFIEDUNSPECIFIED
Date : June 2013
Identification Number : 10.1002/jbm.a.34489
Additional Information : This is the accepted version of the following article: Bioactivity and hemocompatibility study of amorphous hydrogenated carbon coatings produced by pulsed magnetron discharge., J Biomed Mater Res A, 101A, 6 which has been published in final form at http://dx.doi.org/10.1002/jbm.a.34489 . In addition, authors may also transmit, print and share copies with colleagues, provided that there is no systematic distribution of the submitted version, e.g. posting on a listserve, network or automated delivery
Depositing User : Symplectic Elements
Date Deposited : 20 Aug 2014 13:27
Last Modified : 20 Aug 2014 13:27
URI: http://epubs.surrey.ac.uk/id/eprint/745696

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