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Urinary engrailed-2 (EN2) levels predict tumour volume in men undergoing radical prostatectomy for prostate cancer.

Pandha, H, Sorensen, KD, Orntoft, TF, Langley, S, Hoyer, S, Borre, M and Morgan, R (2012) Urinary engrailed-2 (EN2) levels predict tumour volume in men undergoing radical prostatectomy for prostate cancer. BJU Int, 110 (6 Pt B). E287-E292.

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What's known on the subject? and What does the study add? There are a lot of potential prostate cancer biomarkers being evaluated. All aim to improve on the sensitivity and specificity of PSA. EN2 was recently shown by our group to have better sensitivity and specificity than PSA. EN2 is a simple ELISA test and is not dependent on other parameters, even PSA, unlike all the other current biomarkers under evaluation. To date, no marker correlates with the amount of cancer present - the present study shows this positive correlation with EN2 in men undergoing prostatectomy. The potential utility of this work is that by knowing that the level of EN2 corresponds to the amount of cancer present, irrelevant of tumour grade and number of cancer foci, we can define an EN2 level corresponding to small cancers, which can then undergo surveillance. We are conducting a further study that is aimed at determining whether the levels of EN2 in urine can indicate 'significant' vs 'non-significant cancer' using the threshold of 0.5 mL cancer (after Epstein's work).

Item Type: Article
Authors :
Pandha, H
Sorensen, KD
Orntoft, TF
Langley, S
Hoyer, S
Borre, M
Morgan, R
Date : September 2012
Identification Number : 10.1111/j.1464-410X.2012.11208.x
Uncontrolled Keywords : Aged, Homeodomain Proteins, Humans, Male, Middle Aged, Nerve Tissue Proteins, Predictive Value of Tests, Prospective Studies, Prostatectomy, Prostatic Neoplasms, Tumor Burden
Depositing User : Symplectic Elements
Date Deposited : 28 Mar 2017 14:14
Last Modified : 31 Oct 2017 14:57

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