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The role of HOX genes in normal hematopoiesis and acute leukemia.

Alharbi, RA, Pettengell, R, Pandha, HS and Morgan, R (2012) The role of HOX genes in normal hematopoiesis and acute leukemia. Leukemia.

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Abstract

The HOX genes are a highly conserved family of homeodomain-containing transcription factors that specify cell identity in early development and, subsequently, in a number of adult processes including hematopoiesis. The dysregulation of HOX genes is associated with a number of malignancies including acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL), where they have been shown to support the immortalization of leukemic cells both as chimeric partners in fusion genes and when overexpressed in their wild type form. This review covers our current understanding of the role of HOX genes in normal hematopoiesis, AML and ALL, with particular emphasis on the similarities and differences of HOX function in these contexts, their hematopoietic downstream genes targets and implications for therapy.Leukemia accepted article preview online, 5 December 2012; doi:10.1038/leu.2012.356.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Microbial and Cellular Sciences
Authors :
AuthorsEmailORCID
Alharbi, RAUNSPECIFIEDUNSPECIFIED
Pettengell, RUNSPECIFIEDUNSPECIFIED
Pandha, HSUNSPECIFIEDUNSPECIFIED
Morgan, RUNSPECIFIEDUNSPECIFIED
Date : 5 December 2012
Identification Number : 10.1038/leu.2012.356
Additional Information : This is an electronic version of an article published in Leukemia, 5th December (2012), DOI 10.1038/leu.2012.356. Link to the published version: http://dx.doi.org/10.1038/leu.2012.356.
Depositing User : Symplectic Elements
Date Deposited : 25 Jan 2013 09:36
Last Modified : 23 Sep 2013 19:57
URI: http://epubs.surrey.ac.uk/id/eprint/744438

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