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The Expression Levels of MicroRNA-361-5p and Its Target VEGFA Are Inversely Correlated in Human Cutaneous Squamous Cell Carcinoma.

Kanitz, A, Imig, J, Dziunycz, PJ, Primorac, A, Galgano, A, Hofbauer, GF, Gerber, AP and Detmar, M (2012) The Expression Levels of MicroRNA-361-5p and Its Target VEGFA Are Inversely Correlated in Human Cutaneous Squamous Cell Carcinoma. PLoS One, 7 (11).

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Abstract

Vascular endothelial growth factor A (VEGFA) plays a key role in the angiogenesis of human skin. Elevated levels of VEGFA are associated with several pathological conditions, including chronic inflammatory skin diseases and several types of skin cancer. In particular, squamous cell carcinoma (SCC) of the skin, the second most common skin cancer in the general population, is characterized by invasive growth, pronounced angiogenesis and elevated levels of VEGFA. The processing, turnover and production of VEGFA are extensively regulated at the post-transcriptional level, both by RNA-binding proteins and microRNAs (miRNAs). In the present study, we identified a new miRNA recognition element in a downstream conserved region of the VEGFA 3'-UTR. We confirmed the repressive effect of miR-361-5p on this element in vitro, identifying the first target for this miRNA. Importantly, we found that miR-361-5p levels are inversely correlated with VEGFA expression in SCC and in healthy skin, indicating that miR-361-5p could play a role in cancers.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Microbial and Cellular Sciences
Authors :
AuthorsEmailORCID
Kanitz, AUNSPECIFIEDUNSPECIFIED
Imig, JUNSPECIFIEDUNSPECIFIED
Dziunycz, PJUNSPECIFIEDUNSPECIFIED
Primorac, AUNSPECIFIEDUNSPECIFIED
Galgano, AUNSPECIFIEDUNSPECIFIED
Hofbauer, GFUNSPECIFIEDUNSPECIFIED
Gerber, APUNSPECIFIEDUNSPECIFIED
Detmar, MUNSPECIFIEDUNSPECIFIED
Date : 2012
Identification Number : 10.1371/journal.pone.0049568
Depositing User : Symplectic Elements
Date Deposited : 14 Dec 2012 11:40
Last Modified : 23 Sep 2013 19:54
URI: http://epubs.surrey.ac.uk/id/eprint/739707

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