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A diurnal rhythm in glucose uptake in brown adipose tissue revealed by in vivo PET-FDG imaging.

van der Veen, DR, Shao, J, Chapman, S, Matthew Leevy, W and Duffield, GE (2012) A diurnal rhythm in glucose uptake in brown adipose tissue revealed by in vivo PET-FDG imaging. Obesity (Silver Spring).

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Abstract

Using a micro-PET/CT scanner, we have measured (18)F-fluorodeoxyglucose uptake in interscapular brown adipose tissue (iBAT) in C57Bl/6 mice at intervals across a 24-hour light-dark cycle. Our data reveals a strong 24-hour profile of glucose uptake of iBAT, peaking at approximately 9 hours into the light phase of the 12 hour light, 12 hour dark day. BAT is increasingly gaining attention as being involved in metabolic phenotypes and obesity, where BAT, as observed by PET analysis, negatively correlates with obesity and age. Conversely, animals that show perturbations in circadian clocks, behavior and physiology show metabolic phenotypes. The observation of a 24-hour rhythm in glucose uptake in iBAT makes this tissue a candidate site of interaction between metabolic and circadian systems.

Item Type: Article
Authors :
AuthorsEmailORCID
van der Veen, DRUNSPECIFIEDUNSPECIFIED
Shao, JUNSPECIFIEDUNSPECIFIED
Chapman, SUNSPECIFIEDUNSPECIFIED
Matthew Leevy, WUNSPECIFIEDUNSPECIFIED
Duffield, GEUNSPECIFIEDUNSPECIFIED
Date : 26 March 2012
Identification Number : https://doi.org/10.1038/oby.2012.78
Depositing User : Symplectic Elements
Date Deposited : 28 Mar 2017 14:12
Last Modified : 28 Mar 2017 14:12
URI: http://epubs.surrey.ac.uk/id/eprint/736484

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