University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Drug loading, dispersion stability, and therapeutic efficacy in targeted drug delivery with carbon nanotubes

Heister, E, Neves, V, Lamprecht, C, Silva, SRP, Coley, HM and McFadden, J (2012) Drug loading, dispersion stability, and therapeutic efficacy in targeted drug delivery with carbon nanotubes Carbon, 50 (2). 622 - 632. ISSN 0008-6223

[img]
Preview
PDF
2011_08 Heister - Drug loading, dispersion stability, and therapeutic efficacy in targeted drug delivery with CNTs.pdf
Available under License : See the attached licence file.

Download (3MB)
[img]
Preview
PDF
2011_08 Heister - Drug loading, dispersion stability, and therapeutic efficacy in targeted drug delivery with CNTs (supporting information).pdf
Available under License : See the attached licence file.

Download (643kB)
[img]
Preview
PDF (licence)
SRI_deposit_agreement.pdf

Download (33kB)

Abstract

We have designed a drug delivery system for the anti-cancer drugs doxorubicin and mitoxantrone based on carbon nanotubes, which is stable under biological conditions, allows for sustained release, and promotes selectivity through an active targeting scheme. Carbon nanotubes are particularly promising for this area of application due to their high surface area, allowing for high drug loading, and their unique interaction with cellular membranes. We have taken a systematic approach to PEG conjugation in order to create a formulation of stable and therapeutically effective CNTs. The presented drug delivery system may be a means of improving cancer treatment modalities by reducing drug-related side effects.

Item Type: Article
Additional Information: NOTICE: this is the author’s version of a work that was accepted for publication in Carbon. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Carbon, 50(2), February 2012, DOI 10.1016/j.carbon.2011.08.074.
Divisions: Faculty of Engineering and Physical Sciences > Electronic Engineering > Advanced Technology Institute > Nano-Electronics Centre
Depositing User: Symplectic Elements
Date Deposited: 26 Nov 2012 09:32
Last Modified: 23 Sep 2013 19:50
URI: http://epubs.surrey.ac.uk/id/eprint/735956

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800