Drug loading, dispersion stability, and therapeutic efficacy in targeted drug delivery with carbon nanotubes

Heister, E, Neves, V, Lamprecht, C, Silva, SRP, Coley, HM and McFadden, J (2012) Drug loading, dispersion stability, and therapeutic efficacy in targeted drug delivery with carbon nanotubes Carbon, 50 (2). pp. 622-632.

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Abstract

We have designed a drug delivery system for the anti-cancer drugs doxorubicin and mitoxantrone based on carbon nanotubes, which is stable under biological conditions, allows for sustained release, and promotes selectivity through an active targeting scheme. Carbon nanotubes are particularly promising for this area of application due to their high surface area, allowing for high drug loading, and their unique interaction with cellular membranes. We have taken a systematic approach to PEG conjugation in order to create a formulation of stable and therapeutically effective CNTs. The presented drug delivery system may be a means of improving cancer treatment modalities by reducing drug-related side effects.

Item Type:	Article
Divisions :	Faculty of Engineering and Physical Sciences > Electronic Engineering > Advanced Technology Institute > Nano-Electronics Centre
Authors :	Heister, E, Neves, V, Lamprecht, C, Silva, SRP, Coley, HM and McFadden, J
Date :	February 2012
DOI :	10.1016/j.carbon.2011.08.074
Additional Information :	NOTICE: this is the author’s version of a work that was accepted for publication in Carbon. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Carbon, 50(2), February 2012, DOI 10.1016/j.carbon.2011.08.074.
Depositing User :	Symplectic Elements
Date Deposited :	26 Nov 2012 09:32
Last Modified :	06 Jul 2019 05:11
URI:	http://epubs.surrey.ac.uk/id/eprint/735956

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