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Uptake and release of double-walled carbon nanotubes by mammalian cells

Neves, V, Heister, E, Costa, S, Tîlmaciu, C, Borowiak-Palen, E, Giusca, CE, Flahaut, E, Soula, B, Coley, HM, McFadden, J and Silva, SRP (2010) Uptake and release of double-walled carbon nanotubes by mammalian cells Advanced Functional Materials, 20 (19). pp. 3272-3279.

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Abstract

Efforts to develop carbon nanotubes (CNTs) as nano-vehicles for precise and controlled drug and gene delivery, as well as markers for in vivo biomedical imaging, are currently hampered by uncertainties with regard to their cellular uptake, their fate in the body, and their safety. All of these processes are likely to be affected by the purity of CNT preparation, as well as the size and concentration of CNTs used, parameters that are often poorly controlled in biological experiments. It is demonstrated herein that under the experimental conditions of standard transfection methods, DWNTs are taken up by cultured cells but are then released after 24 h with no discernable stress response. The results support the potential therapeutic use of CNTs in many biomedical settings, such as cancer therapy.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering > Advanced Technology Institute
Authors :
AuthorsEmailORCID
Neves, VUNSPECIFIEDUNSPECIFIED
Heister, EUNSPECIFIEDUNSPECIFIED
Costa, SUNSPECIFIEDUNSPECIFIED
Tîlmaciu, CUNSPECIFIEDUNSPECIFIED
Borowiak-Palen, EUNSPECIFIEDUNSPECIFIED
Giusca, CEUNSPECIFIEDUNSPECIFIED
Flahaut, EUNSPECIFIEDUNSPECIFIED
Soula, BUNSPECIFIEDUNSPECIFIED
Coley, HMUNSPECIFIEDUNSPECIFIED
McFadden, JUNSPECIFIEDUNSPECIFIED
Silva, SRPUNSPECIFIEDUNSPECIFIED
Date : 8 October 2010
Identification Number : 10.1002/adfm.201000994
Additional Information : This is the peer reviewed version of the following article: Neves, V, Heister, E, Costa, S, Tîlmaciu, C, Borowiak-Palen, E, Giusca, CE, Flahaut, E, Soula, B, Coley, HM, McFadden, J and Silva, SRP (2010) Uptake and release of double-walled carbon nanotubes by mammalian cells Advanced Functional Materials, 20 (19). 3272 - 3279, which has been published in final form at http://dx.doi.org/10.1002/adfm.201000994. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Depositing User : Symplectic Elements
Date Deposited : 02 Dec 2015 11:17
Last Modified : 02 Dec 2015 11:17
URI: http://epubs.surrey.ac.uk/id/eprint/7318

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