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Systems biology of the metabolism of Mycobacterium tuberculosis

Beste, DJV and McFadden, J (2010) Systems biology of the metabolism of Mycobacterium tuberculosis Biochemical Society Transactions, 38 (5). 1286 - 1289. ISSN 0300-5127

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Abstract

Despite decades of research, many aspects of the biology of Mycobacterium tuberculosis remain unclear, and this is reflected in the antiquated tools available to treat and prevent tuberculosis and consequently this disease remains a serious public health problem. Important discoveries linking the metabolism of M. tuberculosis and pathogenesis has renewed interest in this area of research. Previous experimental studies were limited to the analysis of individual genes or enzymes, whereas recent advances in computational systems biology and high-throughput experimental technologies now allows metabolism to be studied on a genome scale. In the present article, we discuss the progress being made in applying system-level approaches to study the metabolism of this important pathogen.

Item Type: Article
Uncontrolled Keywords: high-throughput approach, metabolism, Mycobacterium tuberculosis, pathogenesis, systems biology, tuberculosis, GENE KNOCKOUT SIMULATION, ESCHERICHIA-COLI, CHORISMATE SYNTHASE, RECONSTRUCTION, PERSISTENCE, NETWORK, TARGET, GROWTH, DISCOVERY, VIRULENCE
Depositing User: Symplectic Elements
Date Deposited: 13 Oct 2011 08:55
Last Modified: 23 Sep 2013 18:46
URI: http://epubs.surrey.ac.uk/id/eprint/7317

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