Ascorbate enhances iron uptake into intestinal cells through formation of a FeCl3-ascorbate complex
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Thumser, AE, Rashed, AA, Sharp, PA and Lodge, JK (2010) Ascorbate enhances iron uptake into intestinal cells through formation of a FeCl3-ascorbate complex Food Chemistry, 123 (2). 281 - 285. ISSN 0308-8146
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Official URL: http://dx.doi.org/10.1016/j.foodchem.2010.04.031
Abstract
It has been well documented that ascorbate enhances iron uptake, with a proposed mechanism based on reduction to the more absorbable ferrous form. We have performed a study on the effects of ascorbate on ferric iron uptake in the human epithelial Caco-2 cell-line. Ascorbate increased uptake in a concentration-dependent manner with a significant difference between iron uptake and reduction. Uptake kinetics are characteristic of a non-essential activator and the formation of an Fe3+–ascorbate complex. This investigation provides evidence that ascorbate enhances the apical uptake of ferric iron into Caco-2 cells through the formation of a Fe3+–ascorbate complex.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Enterocyte iron uptake, Ascorbate, Ferric iron, CACO-2 CELLS, NONHEME IRON, COLORIMETRIC ASSAY, EPITHELIAL-CELLS, EXPRESSION, TRANSPORT, ABSORPTION, DMT1, BIOAVAILABILITY, HUMANS |
| Divisions: | Faculty of Health and Medical Sciences > Biochemistry and Physiology |
| ID Code: | 7253 |
| Deposited By: | Symplectic Elements |
| Deposited On: | 06 Oct 2011 12:36 |
| Last Modified: | 30 Mar 2013 14:36 |
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