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Establishing a practical blood platelet threshold to avoid reporting spurious potassium results due to thrombocytosis

Jones, S, Thurlow, V, Ozevlat, H and Bailey, IR (2005) Establishing a practical blood platelet threshold to avoid reporting spurious potassium results due to thrombocytosis Annals of Clinical Biochemistry, 3. pp. 196-199.

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Abstract

Background: Thrombocytosis is one of several pre-analytical factors which contribute to spuriously high serum potassium concentrations, yet there is little published data to guide analysts in the selection of a specific platelet count threshold above which serum potassium results become unreliable. We have studied the sensitivity and specificity of blood platelet count as a predictor of false elevations in potassium. Methods: Paired serum and plasma potassium measurements together with full blood count were performed for 300 patients. All samples were stored at room temperature and analysed within 4 h of collection. The difference between serum and plasma potassium was plotted against blood platelet count. Results: When the difference (serum-plasma) in potassium concentration was plotted against platelet count, there was a direct linear relationship. Blood platelet counts of >500 x 109/L will detect elevations in serum relative to plasma potassium of >0.5 mmol/L, with a sensitivity of 71% and a specificity of 89%. Conclusion: It is recommended that where blood platelet count is above 500 x 109/L, potassium measurements should be repeated using lithium heparin plasma. When serum potassium results of >5.4 mmol/L are obtained, it is our policy to check the platelet count if a sample is available before reporting results. If available and above 500 x 109/L, potassium results are withheld and plasma requested.

Item Type: Article
Divisions : Faculty of Arts and Social Sciences > Surrey Business School
Authors :
NameEmailORCID
Jones, SUNSPECIFIEDUNSPECIFIED
Thurlow, VUNSPECIFIEDUNSPECIFIED
Ozevlat, HUNSPECIFIEDUNSPECIFIED
Bailey, IRUNSPECIFIEDUNSPECIFIED
Date : 1 May 2005
Identification Number : 10.1258/0004563053857761
Related URLs :
Additional Information : Jones, S, Thurlow, V, Ozevlat, H and Bailey, IR (2005) Establishing a practical blood platelet threshold to avoid reporting spurious potassium results due to thrombocytosis Annals of Clinical Biochemistry, 3. 196 - 199. DOI: 10.1258/0004563053857761 This is the final draft, after peer-review, of a manuscript published in RSM journals: www.rsmpress.com.
Depositing User : Symplectic Elements
Date Deposited : 28 Mar 2017 14:09
Last Modified : 31 Oct 2017 14:44
URI: http://epubs.surrey.ac.uk/id/eprint/722279

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