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Decreased Lempel-Ziv complexity in Alzheimer's disease patients' magnetoencephalograms

Gómez, C, Hornero, R, Fernández, A, Abásolo, D and López, M (2005) Decreased Lempel-Ziv complexity in Alzheimer's disease patients' magnetoencephalograms In: 27th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society, 2005-08-31 - 2005-09-03, Shanghai, PEOPLES R CHINA.

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Abstract

The aim of the present research is to study the magnetoencephalogram (MEG) background activity in patients with Alzheimer's disease (AD) using the Lempel-Ziv (LZ) complexity. We recorded the MEG with a 148-channel whole-head magnetometer (MAGNES 2500 WH, 4D Neuroimaging) in 10 patients with probable AD and 10 age-matched control subjects, during five minutes. Artefact-free epochs were selected for the non-linear analysis. In all MEG channels, the AD patients had lower complexity than control subjects. In 77 of them the differences were statistically significant (p < 0.01). These preliminary results suggest that cognitive dysfunction in AD is associated with a decreased complexity in certain regions of the brain.

Item Type: Conference or Workshop Item (Paper)
Additional Information: Copyright 2005 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.
Uncontrolled Keywords: EEG SYNCHRONIZATION, MUTUAL INFORMATION, ANESTHESIA, DEPTH, STATE
Divisions: Faculty of Engineering and Physical Sciences > Mechanical Engineering Sciences
Depositing User: Symplectic Elements
Date Deposited: 14 Nov 2012 10:50
Last Modified: 23 Sep 2013 19:36
URI: http://epubs.surrey.ac.uk/id/eprint/713802

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