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Rapid, automated measurement of dielectrophoretic forces using DEP-activated microwells.

Broche, LM, Hoettges, KF, Ogin, SL, Kass, GE and Hughes, MP (2011) Rapid, automated measurement of dielectrophoretic forces using DEP-activated microwells. Electrophoresis, 32 (17). 2393 - 2399. ISSN 0173-0835

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Abstract

Dielectrophoresis (DEP) is a physical effect that generates a force on polarisable particles experiencing a non-homogeneous electric field; studying the effect as a function of frequency allows the determination of the electrical properties of that particle, i.e. the electrical permittivity and conductivity. In the past, DEP-based techniques applied to the measurement of one or several cells at a time have been subject to many sources of noise, which result in an ambiguous or inaccurate result. However, improvements are possible by generating more information from the experiments. In this paper, we present a rapid automated system that measures the DEP spectrum from a large population of cells with a low level of noise using the microwell electrodes, based on a method of analysis that provides additional information about the electrical properties of the cells and a new theoretical approach was developed to obtain accurate, bias-free results in <5 min.

Item Type: Article
Additional Information: The definitive version is available at http://onlinelibrary.wiley.com/doi/10.1002/elps.201100063/abstract
Divisions: Faculty of Engineering and Physical Sciences > Mechanical Engineering Sciences
Depositing User: Symplectic Elements
Date Deposited: 29 Oct 2012 20:25
Last Modified: 23 Sep 2013 19:34
URI: http://epubs.surrey.ac.uk/id/eprint/712682

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