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The effects of added salt on the second virial coefficients of the complete proteome of E. coli

Sear, RP (2002) The effects of added salt on the second virial coefficients of the complete proteome of E. coli Journal of Chemical Physics, 118 (11). pp. 5157-5161.

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Bacteria typically have a few thousand different proteins. The number of proteins with a given charge is a roughly Gaussian function of charge - centred near zero, and with a width around ten (in units of the charge on the proton). We have used the charges on E. coli's proteins to estimate the changes in the second virial coefficients of all its proteins as the concentration of a 1:1 salt is increased. The second virial coefficient has dimensions of volume and we find that on average it decreases by about twice the average volume of a protein when the salt concentration is increased from 0.2 to 1 Molar. The standard deviation of the decrease is of the same order. The consequences of this for the complex mixture of proteins inside an E. coli cell, are briefly discussed.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Physics
Authors :
Sear, RP
Date : 13 September 2002
DOI : 10.1063/1.1544556
Related URLs :
Additional Information : Copyright 2002 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics.The following article appeared in Journal of Chemical Physics, 118 (11) 141110 and may be found at
Depositing User : Symplectic Elements
Date Deposited : 28 Sep 2012 08:33
Last Modified : 31 Oct 2017 14:46

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