Specific protein-protein binding in many-component mixtures of proteins
Sear, RP (2003) Specific protein-protein binding in many-component mixtures of proteins Physical Biology, 1 (2 (2004)).
Available under License : See the attached licence file.
Proteins must bind to specific other proteins in vivo in order to function. The proteins must bind only to one or a few other proteins of the of order a thousand proteins typically present in vivo. Using a simple model of a protein, specific binding in many component mixtures is studied. It is found to be a demanding function in the sense that it demands that the binding sites of the proteins be encoded by long sequences of bits, and the requirement for specific binding then strongly constrains these sequences. This is quantified by the capacity of proteins of a given size (sequence length), which is the maximum number of specific-binding interactions possible in a mixture. This calculation of the maximum number possible is in the same spirit as the work of Shannon and others on the maximum rate of communication through noisy channels.
|Additional Information:||Copyright 2003 Institute of Physics. This is the author's accepted manuscript.|
|Divisions:||Faculty of Engineering and Physical Sciences > Physics|
|Deposited By:||Symplectic Elements|
|Deposited On:||24 Aug 2012 09:58|
|Last Modified:||15 Mar 2013 14:34|
Repository Staff Only: item control page