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Specific protein-protein binding in many-component mixtures of proteins

Sear, RP (2003) Specific protein-protein binding in many-component mixtures of proteins Physical Biology, 1 (2 (200).

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Abstract

Proteins must bind to specific other proteins in vivo in order to function. The proteins must bind only to one or a few other proteins of the of order a thousand proteins typically present in vivo. Using a simple model of a protein, specific binding in many component mixtures is studied. It is found to be a demanding function in the sense that it demands that the binding sites of the proteins be encoded by long sequences of bits, and the requirement for specific binding then strongly constrains these sequences. This is quantified by the capacity of proteins of a given size (sequence length), which is the maximum number of specific-binding interactions possible in a mixture. This calculation of the maximum number possible is in the same spirit as the work of Shannon and others on the maximum rate of communication through noisy channels.

Item Type: Article
Additional Information: Copyright 2003 Institute of Physics. This is the author's accepted manuscript.
Related URLs:
Divisions: Faculty of Engineering and Physical Sciences > Physics
Depositing User: Symplectic Elements
Date Deposited: 24 Aug 2012 08:58
Last Modified: 09 Jun 2014 13:16
URI: http://epubs.surrey.ac.uk/id/eprint/712461

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