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Effects of thermal treatments on protein adsorption of Co-Cr-Mo ASTM-F75 alloys.

Duncan, LA, Labeed, FH, Abel, ML, Kamali, A and Watts, JF (2011) Effects of thermal treatments on protein adsorption of Co-Cr-Mo ASTM-F75 alloys. J Mater Sci Mater Med, 22 (6). 1455 - 1464. ISSN 0957-4530

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Abstract

Post-manufacturing thermal treatments are commonly employed in the production of hip replacements to reduce shrinkage voids which can occur in cast components. Several studies have investigated the consequences of these treatments upon the alloy microstructure and tribological properties but none have determined if there are any biological ramifications. In this study the adsorption of proteins from foetal bovine serum (FBS) on three Co-Cr-Mo ASTM-F75 alloy samples with different metallurgical histories, has been studied as a function of protein concentration. Adsorption isotherms have been plotted using the surface concentration of nitrogen as a diagnostic of protein uptake as measured by X-ray photoelectron spectroscopy. The data was a good fit to the Langmuir adsorption isotherm up to the concentration at which critical protein saturation occurred. Differences in protein adsorption on each alloy have been observed. This suggests that development of the tissue/implant interface, although similar, may differ between as-cast (AC) and heat treated samples.

Item Type: Article
Additional Information: The original publication is available at http://www.springerlink.com/content/k7351517867271tn/?MUD=MP
Divisions: Faculty of Engineering and Physical Sciences > Mechanical Engineering Sciences
Depositing User: Symplectic Elements
Date Deposited: 11 Jul 2012 18:24
Last Modified: 23 Sep 2013 19:33
URI: http://epubs.surrey.ac.uk/id/eprint/712192

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