A Randomized Controlled Trial Investigating the Effects of Celecoxib in Patients with Localized Prostate Cancer

Sooriakumaran, P, Coley, HM, Fox, SB, Macanas-Pirard, P, Lovell, DP, Henderson, A, Eden, CG, Miller, PD, Langley, SEM and Laing, RW (2009) A Randomized Controlled Trial Investigating the Effects of Celecoxib in Patients with Localized Prostate Cancer ANTICANCER RESEARCH, 29 (5). pp. 1483-1488.

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Abstract

Cyclooxygenase-2 (COX-2) is associated with tumour promotion, inhibition of apoptosis, angiogenesis and metastasis. Celecoxib, a selective COX-2 inhibitor was investigated, in patients with clinically localized prostate cancer using immunohistochemistry. Patients and Methods: Patients with cT1-2 prostate cancer (n=45) were randomized to celecoxib 400mg b.d. or no treatment for four weeks prior to radical prostatectomy. Histological sections of preoperative biopsy and matched radical prostatectomy specimens were stained for markers of cell proliferation (MIB-1/Ki-67), microvessel density (CD-31 with Weidner scoring), COX-2, apoptosis (TUNEL analysis), angiogenic factors (VEGF and KDR) and HIF-1. Results: Celecoxib decreased tumour cell proliferation, microvessel density, angiogenesis and HIF-1 whilst enhancing apoptosis. These effects approached statistical significance in a multivariate model and the cell proliferation index approached statistical significance on univariate analysis. Conclusion: In this pilot study a 4 week regimen of celecoxib resulted in measurable biological effects in prostate cancer tissue. These findings warrant further investigation.

Item Type:	Article
Authors :	Authors Email ORCID Sooriakumaran, P UNSPECIFIED UNSPECIFIED Coley, HM UNSPECIFIED UNSPECIFIED Fox, SB UNSPECIFIED UNSPECIFIED Macanas-Pirard, P UNSPECIFIED UNSPECIFIED Lovell, DP UNSPECIFIED UNSPECIFIED Henderson, A UNSPECIFIED UNSPECIFIED Eden, CG UNSPECIFIED UNSPECIFIED Miller, PD UNSPECIFIED UNSPECIFIED Langley, SEM UNSPECIFIED UNSPECIFIED Laing, RW UNSPECIFIED UNSPECIFIED
Date :	1 May 2009
Uncontrolled Keywords :	Science & Technology, Life Sciences & Biomedicine, Oncology, Celecoxib, COX-2 inhibitors, prostate cancer, randomized controlled trial, CYCLOOXYGENASE-2 EXPRESSION, RADICAL PROSTATECTOMY, ANGIOGENESIS, THERAPY, CELLS
Related URLs :	Author
Depositing User :	Symplectic Elements
Date Deposited :	28 Mar 2017 14:44
Last Modified :	28 Mar 2017 14:44
URI:	http://epubs.surrey.ac.uk/id/eprint/711612

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