The cyclin-dependent kinase inhibitor p57(Kip2) is epigenetically regulated in carboplatin resistance and results in collateral sensitivity to the CDK inhibitor seliciclib in ovarian cancer.
Coley, HM, Safuwan, NA, Chivers, P, Papacharalbous, E, Giannopoulos, T, Butler-Manuel, S, Madhuri, K, Lovell, DP and Crook, T (2012) The cyclin-dependent kinase inhibitor p57(Kip2) is epigenetically regulated in carboplatin resistance and results in collateral sensitivity to the CDK inhibitor seliciclib in ovarian cancer. Br J Cancer, 106 (3). 482 - 489.
BJC_Coley_et_al._2011.pdf - Accepted Version
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Carboplatin remains a first-line agent in the management of epithelial ovarian cancer (EOC). Unfortunately, platinum-resistant disease ultimately occurs in most patients. Using a novel EOC cell line with acquired resistance to carboplatin: PEO1CarbR, genome-wide micro-array profiling identified the cyclin-dependent kinase inhibitor p57(Kip2) as specifically downregulated in carboplatin resistance. Presently, we describe confirmation of these preliminary data with a variety of approaches.
|Divisions :||Faculty of Health and Medical Sciences > Biochemistry and Physiology|
|Date :||31 January 2012|
|Identification Number :||10.1038/bjc.2011.566|
|Uncontrolled Keywords :||Antineoplastic Agents, Carboplatin, Cell Line, Tumor, Cyclin-Dependent Kinase Inhibitor p27, DNA Methylation, Dose-Response Relationship, Drug, Down-Regulation, Drug Resistance, Neoplasm, Epigenesis, Genetic, Female, Humans, Ovarian Neoplasms, Purines|
|Additional Information :||British Journal of Cancer (2012) 106, 482 – 489 & 2012 Cancer Research UK All rights reserved 0007 – 0920/12|
|Depositing User :||Symplectic Elements|
|Date Deposited :||29 Jun 2012 09:19|
|Last Modified :||23 Sep 2013 19:32|
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