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Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s

Doria, D, Kakolee, KF, Kar, S, Litt, SK, Fiorini, F, Ahmed, H, Green, S, Jeynes, JCJ, Kavanagh, J, Kirby, D , Kirkby, KJ, Merchant, MJ, Nersisyan, G, Prasad, R, Prise, KM, Schettino, G, Zepf, M and Borghesi, M (2012) Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s AIP Advances, 2 (1). 011209-011215.

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The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen’s University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225kKVp X-ray source.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering > Advanced Technology Institute > Ion Beam Centre
Authors :
Doria, D
Kakolee, KF
Kar, S
Litt, SK
Fiorini, F
Ahmed, H
Green, S
Jeynes, JCJ
Kavanagh, J
Kirby, D
Kirkby, KJ
Merchant, MJ
Nersisyan, G
Prasad, R
Prise, KM
Schettino, G
Zepf, M
Borghesi, M
Date : 22 March 2012
DOI : 10.1063/1.3699063
Additional Information : Copyright 2012 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in AIP Advances, 2 011209-011215 and may be found at Doria et al., AIP Advances 2(1), 011209 (2012)
Depositing User : Symplectic Elements
Date Deposited : 23 Jul 2012 14:58
Last Modified : 31 Oct 2017 14:38

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