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A focused scanning vertical beam for charged particle irradiation of living cells with single counted particles

Merchant M J, , Jeynes, JCJ, Grime, GW, Palitsin, V, Tullis, IDC, Barber, P, Vojnovic, B, Webb, RP and Kirkby, KJ (2012) A focused scanning vertical beam for charged particle irradiation of living cells with single counted particles Radiation Research: an international journal, forthc.

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Abstract

The Surrey vertical beam is a new facility for targeted irradiation of cells in medium with singly counted ions. A duo-plasmatron ion source and a 2 MV Tandem accelerator supply a range of ions from protons to calcium for this beamline, with energy ranges from 0.5 to 12 MeV. A magnetic quadrupole triplet lens is used to focus the beam of ions. We present the design of this beamline, and early results showing the capability to count single ions with 98% certainty on CR-39 track etch. We also show that the beam targeting accuracy is within 5 microns and selectively target human broblasts with a <5 m carbon beam, using H2AX immuno uorescence to demonstrate which cell nuclei were irradiated. We discuss future commissioning steps necessary to achieve sub-micron targeting accuracy with this beamline.

Item Type: Article
Authors :
AuthorsEmailORCID
Merchant M J, UNSPECIFIEDUNSPECIFIED
Jeynes, JCJUNSPECIFIEDUNSPECIFIED
Grime, GWUNSPECIFIEDUNSPECIFIED
Palitsin, VUNSPECIFIEDUNSPECIFIED
Tullis, IDCUNSPECIFIEDUNSPECIFIED
Barber, PUNSPECIFIEDUNSPECIFIED
Vojnovic, BUNSPECIFIEDUNSPECIFIED
Webb, RPUNSPECIFIEDUNSPECIFIED
Kirkby, KJUNSPECIFIEDUNSPECIFIED
Date : 3 May 2012
Identification Number : https://doi.org/10.1667/RR2847.1
Depositing User : Symplectic Elements
Date Deposited : 28 Mar 2017 14:44
Last Modified : 28 Mar 2017 14:44
URI: http://epubs.surrey.ac.uk/id/eprint/663637

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