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VBM lesion detection depends on the normalization template: a study using simulated atrophy

Shen, S, Szameitat, AJ and Sterr, Annette (2007) VBM lesion detection depends on the normalization template: a study using simulated atrophy Magnetic Resonance Imaging, 25 (10). pp. 1385-1396.

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Abstract

Structural neuroimaging studies are of great interest for neuroscientists, which are reflected in the rising number of papers using voxel-based morphometry (VBM). One major step in VBM is the transformation of images to a standard template, a spatial normalization necessary to ensure that homologous regions are compared while interindividual characteristics are maintained. Templates can be created in different ways, and this may affect the likelihood that differences in gray/white matter density between groups are detected. However, studies investigating the interaction of normalization template and VBM accuracy are sparse. Existing work is based on patient control group comparisons, and the emerging results are inconclusive. The present paper therefore used simulated atrophy in a simplified one-lesion model to systematically study template effects of VBM analyses implemented in SPM. This allowed us to characterize template-specific biases in reference to a set of prespecified parameters of anatomical difference. The data suggest that the likelihood of correctly detecting the prespecified lesion is modulated by the normalization template. Thereby, the relationship between template-related VBM accuracy and specific group/study characteristics is complex, and there does not appear to be one `best template.' Our data show that template effects are critical and clearly suggest that the choice of template needs careful consideration in relation to the specific research question and study constraints. (c) 2007 Elsevier Inc. All rights reserved.

Item Type: Article
Divisions : Faculty of Arts and Social Sciences
Authors :
NameEmailORCID
Shen, SUNSPECIFIEDUNSPECIFIED
Szameitat, AJUNSPECIFIEDUNSPECIFIED
Sterr, AnnetteA.Sterr@surrey.ac.ukUNSPECIFIED
Date : 30 April 2007
Identification Number : 10.1016/j.mri.2007.03.025
Copyright Disclaimer : © 2007. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords : voxel-based morphometry spatial normalization template simulated atrophy VOXEL-BASED MORPHOMETRY TEMPORAL-LOBE EPILEPSY GRAY-MATTER DENSITY STATISTICAL-ANALYSIS BRAIN STRUCTURE SCHIZOPHRENIA DISEASE INTELLIGENCE CHILDHOOD HEALTHY
Depositing User : Symplectic Elements
Date Deposited : 05 Sep 2017 10:32
Last Modified : 05 Sep 2017 10:32
URI: http://epubs.surrey.ac.uk/id/eprint/639719

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