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The effect of repeated short sleep deprivations on sleep and the sleep EEG

Yasenkov, Roman and Deboer, Tom (2008) The effect of repeated short sleep deprivations on sleep and the sleep EEG In: 19th Congress of the European Sleep Research Society, 9-13 September 2008, Glasgow.

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Abstract

Sleep regulation is realized by homeostatic and circadian processes. The homeostatic component is reflected by slow-wave activity (SWA) in the NREM sleep EEG, while high frequency activity (>10 Hz, HFA) is thought to be influenced by the circadian factors. We investigated whether daily changes in sleep and HFA are independent of changes in SWA. Rats (n=4) were implanted with EEG and EMG electrodes and kept in 12h:12h light/dark cycles for the recovery period. Subsequently the animals adapted to constant dark conditions (DD) for at least 1 week. A baseline (BL) day was recorded followed by “short-day protocol” - 2h sleep deprivation followed by 2 h rest for 2 days. The vigilance states were determined and EEG spectral analysis between 0.1-25.0 Hz was performed. The amount of sleep over 24 h of the “short-day protocol” was less (43.3±1.7% SE) compared to baseline (51.5 ±1.2%, p<0.005, t-test). Circadian changes in vigilance states was reduced to 25 % of baseline (p<0.05, t-test). SWA (1.1-4.0 Hz) in NREM sleep did not show a significant circadian modulation (p>0.5, ANOVA 4-h intervals) during the protocol, while the power density in spindle range (11.1-15.0 Hz) and frequencies between 15.1-25.0 Hz showed strong circadian modulation (p<0.05, ANOVA 4-h intervals) which did not differ from baseline (p>0.5, ANOVA). Analysis of the time course of SWA and power density in the spindle range in the first 7 min of a NREM sleep episode confirmed these results, with no circadian modulation in SWA but circadian changes in the spindle range and a time course within the NREM sleep episode identical to baseline. The present data show that, in a contrast to SWA, HFA is not influenced by sleep homeostatic mechanisms and displays significant circadian modulation with endogenous origin. Supported by EU Grant LSHM-CT-2005-518189.

Item Type: Conference or Workshop Item (Conference Poster)
Divisions : Faculty of Health and Medical Sciences
Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Biochemical Sciences
Authors :
NameEmailORCID
Yasenkov, Romanr.yasenkov@surrey.ac.ukUNSPECIFIED
Deboer, Tomtom.de_boer@lumc.nlUNSPECIFIED
Date : September 2008
Depositing User : Roman Yasenkov
Date Deposited : 28 Mar 2017 14:44
Last Modified : 31 Oct 2017 14:37
URI: http://epubs.surrey.ac.uk/id/eprint/600589

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