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Influence of regulation logic on the easiness of evolving sustained oscillation for gene regulatory networks

Jin, Y, Sendhoff, B and Meng, Y (2009) Influence of regulation logic on the easiness of evolving sustained oscillation for gene regulatory networks

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Abstract

This paper investigates empirically the influence of regulation logic on the dynamics of two computational models of genetic regulatory network motifs. The gene regulatory network motifs considered in this work consist of three genes with both positive and negative feedback loops. Two forms of fuzzy logic, namely, the Zadeh operators and the probabilistic operators, as well as the summation logic have been investigated. We show that the easiness of evolving sustained oscillation, and the stability of the evolved oscillation depend both on the regulation logic and on the consistency of the regulation on the target gene.

Item Type: Conference or Workshop Item (Paper)
Additional Information: © 2009 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Divisions: Faculty of Engineering and Physical Sciences > Computing Science
Depositing User: Symplectic Elements
Date Deposited: 06 Jul 2012 13:39
Last Modified: 23 Sep 2013 19:27
URI: http://epubs.surrey.ac.uk/id/eprint/532823

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