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An investigation of clinical and immunological events following repeated aerodigestive tract challenge infections with live Mycobacterium bovis Bacille Calmette Guérin.

Schreiber, F, Huo, Z, Giemza, R, Woodrow, M, Fenner, N, Stephens, Z, Dougan, G, Prideaux, S, Castello-Branco, LR and Lewis, DJ (2010) An investigation of clinical and immunological events following repeated aerodigestive tract challenge infections with live Mycobacterium bovis Bacille Calmette Guérin. Vaccine, 28 (33). pp. 5427-5431.

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Abstract

Bacille Calmette Guérin substrain Moreau Rio de Janeiro is an attenuated strain of Mycobacterium bovis that has been used extensively as an oral tuberculosis vaccine. We assessed its potential as a challenge model to study clinical and immunological events following repeated mycobacterial gut infection. Seven individuals received three oral challenges with approximately 10(7) viable bacilli. Clinical symptoms, T-cell responses and gene expression patterns in peripheral blood were monitored. Clinical symptoms were relatively mild and declined following each oral challenge. Delayed T-cell responses were observed, and limited differential gene expression detected by microarrays. Oral challenge with BCG Moreau Rio de Janeiro vaccine was immunogenic in healthy volunteers, limiting its potential to explore clinical innate immune responses, but with low reactogenicity.

Item Type: Article
Authors :
NameEmailORCID
Schreiber, FUNSPECIFIEDUNSPECIFIED
Huo, ZUNSPECIFIEDUNSPECIFIED
Giemza, RUNSPECIFIEDUNSPECIFIED
Woodrow, MUNSPECIFIEDUNSPECIFIED
Fenner, NUNSPECIFIEDUNSPECIFIED
Stephens, ZUNSPECIFIEDUNSPECIFIED
Dougan, GUNSPECIFIEDUNSPECIFIED
Prideaux, SUNSPECIFIEDUNSPECIFIED
Castello-Branco, LRUNSPECIFIEDUNSPECIFIED
Lewis, DJUNSPECIFIEDUNSPECIFIED
Date : 26 July 2010
Identification Number : 10.1016/j.vaccine.2010.06.005
Uncontrolled Keywords : Adolescent, Adult, Female, Humans, Immunity, Innate, Intestinal Diseases, Male, Middle Aged, Mycobacterium Infections, Mycobacterium bovis, T-Lymphocytes, Tuberculosis Vaccines
Depositing User : Symplectic Elements
Date Deposited : 28 Mar 2017 14:42
Last Modified : 31 Oct 2017 14:33
URI: http://epubs.surrey.ac.uk/id/eprint/486739

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