Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s
Doria, D, Kakolee, KF, Kar, S, Litt, SK, Fiorini, F, Ahmed, H, Green, S, Jeynes, JCJ, Kavanagh, J, Kirby, D, Kirkby, KJ, Merchant, MJ, Nersisyan, G, Prasad, R, Prise, KM, Schettino, G, Zepf, M and Borghesi, M (2012) Biological effectiveness on live cells of laser driven protons at dose rates exceeding 109 Gy/s AIP Advances, 2. 011209 - 011215. ISSN 2158-3226
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The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen’s University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225kKVp X-ray source.
Copyright 2012 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics.
The following article appeared in AIP Advances, 2 011209-011215 and may be found at D. Doria et al., AIP Advances 2, 011209 (2012)
|Divisions:||Faculty of Engineering and Physical Sciences > Electronic Engineering > Advanced Technology Institute > Ion Beam Centre|
|Depositing User:||Symplectic Elements|
|Date Deposited:||19 Apr 2012 08:57|
|Last Modified:||23 Sep 2013 19:23|
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