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Analytical detection and biological assay of antileukemic drug using gold nanoparticles

Selvaraj, V, Alagar, M and Hamerton, I (2006) Analytical detection and biological assay of antileukemic drug using gold nanoparticles ELECTROCHIM ACTA, 52 (3). 1152 - 1160. ISSN 0013-4686

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Gold nanoparticles are reported and evaluated as probes for the detection of anticancer drug 5-fluorouracil (5FU). The nature of binding between 5FU and gold nanoparticles via complexation is investigated using ultraviolet visible spectrophotometry, cyclic voltammetry, transmission electron microscopy, fluorescence and Fourier transform infrared (FTIR) spectroscopy. The bound antileukemic drug is fluorescent and the quenching property of gold nanoparticles could be exploited for biological investigations. The 5FU-colloidal gold complex (Au5FU) is observed to have appreciable antibacterial and antifungal activity against Micrococcus luteus, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Aspergillus fumigatus, and Aspergillus niger. The experimental studies suggest that gold nanoparticles have the potential to be used as effective carriers for anticancer drugs.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
Date : 12 November 2006
Identification Number : 10.1016/j.electacta.2006.07.016
Uncontrolled Keywords : gold nanoparticles, 6-mercaptopurine, microbial studies, antibacterial and antifungal activity, 6-MERCAPTOPURINE, MONOLAYERS, AU, 6-THIOGUANINE, NANOSPHERES, ELECTRODES, DELIVERY, BINDING, SURFACE, CELLS
Additional Information : NOTICE: this is the author’s version of a work that was accepted for publication in Electrochimica Acta. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Electrochimica Acta, 52(3), November 2006, DOI 10.1016/j.electacta.2006.07.016
Depositing User : Symplectic Elements
Date Deposited : 21 Mar 2012 12:36
Last Modified : 23 Sep 2013 19:19

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