Analytical detection and biological assay of antileukemic drug using gold nanoparticles
Selvaraj, V, Alagar, M and Hamerton, I (2006) Analytical detection and biological assay of antileukemic drug using gold nanoparticles ELECTROCHIM ACTA, 52 (3). pp. 1152-1160.
Document_in_Windows_Internet_Explorer.pdf - Accepted version Manuscript
Gold nanoparticles are reported and evaluated as probes for the detection of anticancer drug 5-fluorouracil (5FU). The nature of binding between 5FU and gold nanoparticles via complexation is investigated using ultraviolet visible spectrophotometry, cyclic voltammetry, transmission electron microscopy, fluorescence and Fourier transform infrared (FTIR) spectroscopy. The bound antileukemic drug is fluorescent and the quenching property of gold nanoparticles could be exploited for biological investigations. The 5FU-colloidal gold complex (Au5FU) is observed to have appreciable antibacterial and antifungal activity against Micrococcus luteus, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Aspergillus fumigatus, and Aspergillus niger. The experimental studies suggest that gold nanoparticles have the potential to be used as effective carriers for anticancer drugs.
|Divisions :||Faculty of Engineering and Physical Sciences > Chemistry|
|Date :||12 November 2006|
|Identification Number :||10.1016/j.electacta.2006.07.016|
|Uncontrolled Keywords :||gold nanoparticles, 6-mercaptopurine, microbial studies, antibacterial and antifungal activity, 6-MERCAPTOPURINE, MONOLAYERS, AU, 6-THIOGUANINE, NANOSPHERES, ELECTRODES, DELIVERY, BINDING, SURFACE, CELLS|
|Additional Information :||NOTICE: this is the author’s version of a work that was accepted for publication in Electrochimica Acta. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Electrochimica Acta, 52(3), November 2006, DOI 10.1016/j.electacta.2006.07.016|
|Depositing User :||Symplectic Elements|
|Date Deposited :||21 Mar 2012 12:36|
|Last Modified :||23 Sep 2013 19:19|
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