Force localization in contracting cell layers
Edwards, CM and Schwarz, US (2011) Force localization in contracting cell layers Physical Review Letters, 107 (12).
Available under License : See the attached licence file.
Epithelial cell layers on soft elastic substrates or pillar arrays are commonly used as model systems for investigating the role of force in tissue growth, maintenance and repair. Here we show analytically that the experimentally observed localization of traction forces to the periphery of the cell layers does not necessarily imply increased local cell activity, but follows naturally from the elastic problem of a finite-sized contractile layer coupled to an elastic foundation. For homogeneous contractility, the force localization is determined by one dimensionless parameter interpolating between linear and exponential force profiles for the extreme cases of very soft and very stiff substrates, respectively. If contractility is sufficiently increased at the periphery, outward directed displacements can occur at intermediate positions. We also show that anisotropic extracellular stiffness can lead to force localization in the stiffer direction, as observed experimentally.
|Divisions :||Faculty of Engineering and Physical Sciences > Mathematics|
|Identification Number :||https://doi.org/10.1103/PhysRevLett.107.128101|
|Additional Information :||Copyright 2011 The American Physical Society.|
|Depositing User :||Symplectic Elements|
|Date Deposited :||19 Mar 2012 12:36|
|Last Modified :||23 Sep 2013 19:19|
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