Carbon nanotube-based transducers for immunoassays
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Lynam, C, Gilmartin, N, Minett, AI, O'Kennedy, R and Wallace, G (2009) Carbon nanotube-based transducers for immunoassays CARBON, 47 (10). 2337 - 2343. ISSN 0008-6223
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Official URL: http://dx.doi.org/10.1016/j.carbon.2009.04.017
Abstract
The attachment of mouse immunoglobulin G (IgG) and anti-mouse IgG antibodies onto carbon nanotubes (CNTs), using either non-covalent or covalent means was investigated. The resultant CNTs were characterised using a variety of techniques including enzyme-linked and fluorescence-linked immunoassays, UV-visible-NIR and Raman spectroscopy, transmission electron microscopy and cyclic voltammetry. TEM images of the adsorbed antibody on the CNTs show that the covalent modification approach was successful, whereas the non-covalent approach resulted in no electrochemically detectable labelled antibody. Direct electrical communication between CNTs covalently linked to peroxidase-labelled antibodies was observed during cyclic voltammetry, which suggests applications in developing carbon-nanotube-based immunosensors. (C) 2009 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Science & Technology, Physical Sciences, Technology, Chemistry, Physical, Materials Science, Multidisciplinary, Chemistry, Materials Science, DIRECT ELECTROCHEMISTRY, BIOSENSORS, ELECTRODE, BEHAVIOR, FUNCTIONALIZATION, IMMOBILIZATION |
| Divisions: | Faculty of Engineering and Physical Sciences > Chemistry |
| Related URLs: | |
| ID Code: | 2979 |
| Deposited By: | Symplectic Elements |
| Deposited On: | 14 Jun 2011 16:37 |
| Last Modified: | 11 May 2013 14:39 |
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