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Carbon nanotube-based transducers for immunoassays

Lynam, C, Gilmartin, N, Minett, AI, O'Kennedy, R and Wallace, G (2009) Carbon nanotube-based transducers for immunoassays CARBON, 47 (10). 2337 - 2343. ISSN 0008-6223

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The attachment of mouse immunoglobulin G (IgG) and anti-mouse IgG antibodies onto carbon nanotubes (CNTs), using either non-covalent or covalent means was investigated. The resultant CNTs were characterised using a variety of techniques including enzyme-linked and fluorescence-linked immunoassays, UV-visible-NIR and Raman spectroscopy, transmission electron microscopy and cyclic voltammetry. TEM images of the adsorbed antibody on the CNTs show that the covalent modification approach was successful, whereas the non-covalent approach resulted in no electrochemically detectable labelled antibody. Direct electrical communication between CNTs covalently linked to peroxidase-labelled antibodies was observed during cyclic voltammetry, which suggests applications in developing carbon-nanotube-based immunosensors. (C) 2009 Elsevier Ltd. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Science & Technology, Physical Sciences, Technology, Chemistry, Physical, Materials Science, Multidisciplinary, Chemistry, Materials Science, DIRECT ELECTROCHEMISTRY, BIOSENSORS, ELECTRODE, BEHAVIOR, FUNCTIONALIZATION, IMMOBILIZATION
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Divisions: Faculty of Engineering and Physical Sciences > Chemistry
Depositing User: Symplectic Elements
Date Deposited: 14 Jun 2011 15:37
Last Modified: 23 Sep 2013 18:42

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