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SCN-AVP release of mPer1/mPer2 double-mutant mice in vitro.

van der Veen, DR, Mulder, EG, Oster, H, Gerkema, MP and Hut, RA (2008) SCN-AVP release of mPer1/mPer2 double-mutant mice in vitro. J Circadian Rhythms, 6 (5). ISSN 1740-3391

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Abstract

Circadian organisation of behavioural and physiological rhythms in mammals is largely driven by the clock in the suprachiasmatic nuclei (SCN) of the hypothalamus. In this clock, a molecular transcriptional repression and activation mechanism generates near 24 hour rhythms. One of the outputs of the molecular clock in specific SCN neurons is arginine-vasopressin (AVP), which is responsive to transcriptional activation by clock gene products. As negative regulators, the protein products of the period genes are thought to repress transcriptional activity of the positive limb after heterodimerisation with CRYPTOCHROME. When both the Per1 and Per2 genes are dysfunctional by targeted deletion of the PAS heterodimer binding domain, mice lose circadian organization of behaviour upon release into constant environmental conditions. To which degree the period genes are involved in the control of AVP output is unknown.

Item Type: Article
Additional Information: © 2008 van der Veen et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Divisions: Faculty of Health and Medical Sciences > Biochemistry and Physiology
Depositing User: Symplectic Elements
Date Deposited: 13 Jun 2012 13:09
Last Modified: 23 Sep 2013 19:17
URI: http://epubs.surrey.ac.uk/id/eprint/285510

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