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Researching Bladder Afferents-Determining the Effects of beta(3)-Adrenergic Receptor Agonists and Botulinum Toxin Type-A

Kanai, A, Wyndaele, J-J, Andersson, K-E, Fry, C, Ikeda, Y, Zabbarova, I and De Wachter, S (2011) Researching Bladder Afferents-Determining the Effects of beta(3)-Adrenergic Receptor Agonists and Botulinum Toxin Type-A NEUROUROLOGY AND URODYNAMICS, 30 (5). pp. 684-691.

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Abstract

A substantial portion of the current research on lower urinary tract dysfunction is focused on afferent mechanisms. The main goals are to define and modulate the signaling pathways by which afferent information is generated, enhanced and conveyed to the central nervous system. Alterations in bladder afferent mechanisms are a potential source of voiding dysfunction and an emerging source for drug targets. Established drug therapies such as muscarinic receptor antagonists, and two emerging therapies, β3-adrenergic receptor agonists and botulinum toxin type-A, may act partly through afferent mechanisms. This review focuses on these two new principles and new and established methods for determining their sites of action. It also provides brief information on the innervation of the bladder, afferent receptors and transmitters and how these may communicate with the urothelium, interstitial cells and detrusor smooth muscle to regulate micturition. Peripheral and central mechanisms of afferent sensitization and myogenic mechanisms that lead to detrusor overactivity, overactive bladder symptoms and urgency sensations are also covered. This work is the result from ‘Think Tank’ presentations, and the lengthy discussions that followed, at the 2010 International Consultation on Incontinence Research Society meeting in Bristol, UK. Neurourol. Urodynam. Neurourol. Urodynam. 30:684–691, 2011. © 2011 Wiley-Liss, Inc

Item Type: Article
Subjects : Biological Sciences
Divisions : Faculty of Health and Medical Sciences
Authors :
AuthorsEmailORCID
Kanai, AUNSPECIFIEDUNSPECIFIED
Wyndaele, J-JUNSPECIFIEDUNSPECIFIED
Andersson, K-EUNSPECIFIEDUNSPECIFIED
Fry, CUNSPECIFIEDUNSPECIFIED
Ikeda, YUNSPECIFIEDUNSPECIFIED
Zabbarova, IUNSPECIFIEDUNSPECIFIED
De Wachter, SUNSPECIFIEDUNSPECIFIED
Date : 1 June 2011
Identification Number : 10.1002/nau.21102
Copyright Disclaimer : This is the peer reviewed version of the following article: Kanai, A, Wyndaele, J-J, Andersson, K-E, Fry, C, Ikeda, Y, Zabbarova, I and De Wachter, S (2011) Researching Bladder Afferents-Determining the Effects of beta(3)-Adrenergic Receptor Agonists and Botulinum Toxin Type-A NEUROUROLOGY AND URODYNAMICS, 30 (5). 684 - 691, which has been published in final form at http://dx.doi.org/10.1002/nau.21102 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Uncontrolled Keywords : Science & Technology, Life Sciences & Biomedicine, Urology & Nephrology, UROLOGY & NEPHROLOGY, beta(3)-adrenergic receptor agonists, bladder afferents, botulinum toxin type-A, optical mapping, SPINAL-CORD-INJURY, HUMAN URINARY-BLADDER, PELVIC NERVE, INTERSTITIAL CYSTITIS, OVERACTIVE BLADDER, FUNCTIONAL-ROLE, NITRIC-OXIDE, MICE REVEAL, ATP RELEASE, GUINEA-PIG
Related URLs :
Additional Information : This is the peer reviewed version of the following article: Kanai, A, Wyndaele, J-J, Andersson, K-E, Fry, C, Ikeda, Y, Zabbarova, I and De Wachter, S (2011) Researching Bladder Afferents-Determining the Effects of beta(3)-Adrenergic Receptor Agonists and Botulinum Toxin Type-A NEUROUROLOGY AND URODYNAMICS, 30 (5). 684 - 691, which has been published in final form at http://dx.doi.org/10.1002/nau.21102 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Depositing User : Symplectic Elements
Date Deposited : 08 Mar 2016 15:17
Last Modified : 08 Mar 2016 15:17
URI: http://epubs.surrey.ac.uk/id/eprint/285472

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