A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference
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Archer, SN, Robilliard, DL, Skene, DJ, Smits, M, Williams, A, Arendt, J and von Schantz, M (2003) A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference SLEEP, 26 (4). 413 - 415. ISSN 0161-8105
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Official URL: http://www.journalsleep.org/ViewAbstract.aspx?pid=...
Abstract
Study objectives: To investigate the link between extreme diurnal preference, delayed sleep phase syndrome (DSPS) and a length polymorphism in Per3. Design: Subjects were genotyped using PCR. Patients or participants: Subjects with defined diurnal preference as determined by the Horne-Östberg questionnaire and DSPS patients. Measurements and results: The Per3 polymorphism correlated significantly with extreme diurnal preference, the longer allele associating with morningness and the shorter allele with eveningness. The shorter allele was strongly associated with the DSPS patients, 75% of whom were homozygous. Conclusion: The length of the Per3 repeat region identifies a potential genetic marker for extreme diurnal preference.
| Item Type: | Article |
|---|---|
| Additional Information: | Posted with permission from the American Academy of Sleep Medicine. |
| Uncontrolled Keywords: | Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences, Neurosciences & Neurology, circadian rhythms, phosphorylation, polymorphism (genetics), protein kinases, sleep disorder, circadian rhythm, PERIOD, ASSOCIATION, PROTEINS, HUMANS |
| Divisions: | Faculty of Health and Medical Sciences > Biochemistry and Physiology |
| ID Code: | 2847 |
| Deposited By: | Symplectic Elements |
| Deposited On: | 08 Sep 2011 09:16 |
| Last Modified: | 14 Jun 2013 02:34 |
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