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A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference

Archer, SN, Robilliard, DL, Skene, DJ, Smits, M, Williams, A, Arendt, J and von Schantz, M (2003) A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference SLEEP, 26 (4). 413 - 415. ISSN 0161-8105

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Abstract

Study objectives: To investigate the link between extreme diurnal preference, delayed sleep phase syndrome (DSPS) and a length polymorphism in Per3. Design: Subjects were genotyped using PCR. Patients or participants: Subjects with defined diurnal preference as determined by the Horne-Östberg questionnaire and DSPS patients. Measurements and results: The Per3 polymorphism correlated significantly with extreme diurnal preference, the longer allele associating with morningness and the shorter allele with eveningness. The shorter allele was strongly associated with the DSPS patients, 75% of whom were homozygous. Conclusion: The length of the Per3 repeat region identifies a potential genetic marker for extreme diurnal preference.

Item Type: Article
Additional Information: Posted with permission from the American Academy of Sleep Medicine.
Uncontrolled Keywords: Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences, Neurosciences & Neurology, circadian rhythms, phosphorylation, polymorphism (genetics), protein kinases, sleep disorder, circadian rhythm, PERIOD, ASSOCIATION, PROTEINS, HUMANS
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Divisions: Faculty of Health and Medical Sciences > Biochemistry and Physiology
Depositing User: Symplectic Elements
Date Deposited: 08 Sep 2011 08:16
Last Modified: 23 Sep 2013 18:40
URI: http://epubs.surrey.ac.uk/id/eprint/2847

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