Antigen-induced immunomodulation in the pathogenesis of atherosclerosis
Milioti, N, Bermudez-Fajardo, A, Penichet, ML and Oviedo-Orta, E (2008) Antigen-induced immunomodulation in the pathogenesis of atherosclerosis CLINICAL & DEVELOPMENTAL IMMUNOLOGY . ? - ?. ISSN 1740-2522
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Official URL: http://www.hindawi.com/journals/cdi/2008/723539.ht...
Atherosclerosis is a chronic inflammatory disorder characterised by the accumulation of monocytes/macrophages, smooth muscle cells, and lymphocytes within the arterial wall in response to the release of proinflammatory molecules. Such accumulation results in the formation of the atherosclerotic plaque, which would eventually evolve to complications such as total artery occlusion, rupture, calcification, or aneurysm. Although the molecular mechanism responsible for the development of atherosclerosis is not completely understood, it is clear that the immune system plays a key role in the development of the atherosclerotic plaque and in its complications. There are multiple antigenic stimuli that have been associated with the pathogenesis of atherosclerosis. Most of these stimuli come from modified self-molecules such as oxidised low-density lipoproteins (oxLDLs), eta2glycoprotein1 (β2GP1), lipoprotein a (LP(a)), heat shock proteins (HSPs), and protein components of the extracellular matrix such as collagen and fibrinogen in the form of advanced glycation-end (AGE) products. In addition, several foreign antigens including bacteria such as Porphyromonas gingivalis and Chlamydia pneumoniae and viruses such as enterovirus and cytomegalovirus have been associated with atherosclerosis as potentially causative or bystander participants, adding another level of complexity to the analysis of the pathophysiology of atherosclerosis. The present review summarises the most important scientific findings published within the last two decades on the importance of antigens, antigen stimulation, and adaptive immune responses in the development of atherosclerotic plaques.
|Uncontrolled Keywords:||Science & Technology, Life Sciences & Biomedicine, Immunology, LOW-DENSITY-LIPOPROTEIN, HELICOBACTER-PYLORI INFECTION, HEAT-SHOCK PROTEINS, RECEPTOR-DEFICIENT MICE, SMOOTH-MUSCLE-CELLS, CHLAMYDIA-PNEUMONIAE DNA, CORONARY-ARTERY-DISEASE, GLYCATION END-PRODUCTS, HERPES-SIMPLEX-VIRUS, SYSTEMIC-LUPUS-ERYTHEMATOSUS|
|Divisions:||Faculty of Health and Medical Sciences > Microbial and Cellular Sciences|
|Deposited By:||Melanie Hughes|
|Deposited On:||02 Nov 2010 14:03|
|Last Modified:||08 Jun 2013 16:20|
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