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Functional Magnetic Resonance Imaging-Assessed Brain Responses during an Executive Task Depend on Interaction of Sleep Homeostasis, Circadian Phase, and PER3 Genotype

Vandewalle, G, Archer, SN, Wuillaume, C, Balteau, E, Degueldre, C, Luxen, A, Maquet, P and Dijk, DJ (2009) Functional Magnetic Resonance Imaging-Assessed Brain Responses during an Executive Task Depend on Interaction of Sleep Homeostasis, Circadian Phase, and PER3 Genotype J NEUROSCI, 29 (25). 7948 - 7956. ISSN 0270-6474

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Abstract

Cognition is regulated across the 24 h sleep-wake cycle by circadian rhythmicity and sleep homeostasis through unknown brain mechanisms. We investigated these mechanisms in a functional magnetic resonance imaging study of executive function using a working memory 3-back task during a normal sleep-wake cycle and during sleep loss. The study population was stratified according to homozygosity for a variable-number (4 or 5) tandem-repeat polymorphism in the coding region of the clock gene PERIOD3. This polymorphism confers vulnerability to sleep loss and circadian misalignment through its effects on sleep homeostasis. In the less-vulnerable genotype, no changes were observed in brain responses during the normal-sleep wake cycle. During sleep loss, these individuals recruited supplemental anterior frontal, temporal and subcortical regions, while executive function was maintained. In contrast, in the vulnerable genotype, activation in a posterior prefrontal area was already reduced when comparing the evening to the morning during a normal sleep-wake cycle. Furthermore, in the morning after a night of sleep loss, widespread reductions in activation in prefrontal, temporal, parietal and occipital areas were observed in this genotype. These differences occurred in the absence of genotype-dependent differences in circadian phase. The data show that dynamic changes in brain responses to an executive task evolve across the sleep-wake and circadian cycles in a regionally specific manner that is determined by a polymorphism which affects sleep homeostasis. The findings support a model of individual differences in executive control, in which the allocation of prefrontal resources is constrained by sleep pressure and circadian phase.

Item Type: Article
Uncontrolled Keywords: WORKING-MEMORY TASK, INTERINDIVIDUAL DIFFERENCES, COGNITIVE PERFORMANCE, NEURAL BASIS, DEPRIVATION, ACTIVATION, POLYMORPHISM, ALERTNESS, HUMANS, WAKE
Divisions: Faculty of Health and Medical Sciences > Biochemistry and Physiology
Depositing User: Melanie Hughes
Date Deposited: 17 Nov 2010 16:40
Last Modified: 24 Jan 2013 09:09
URI: http://epubs.surrey.ac.uk/id/eprint/2552

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