Non-alcoholic fatty liver disease: the hepatic consequence of obesity and the metabolic syndrome.
Moore, JB (2010) Non-alcoholic fatty liver disease: the hepatic consequence of obesity and the metabolic syndrome. Proc Nutr Soc, 69 (2). 211 - 220. ISSN 0029-6651
JBMoore_NutSocPaper_forSSOL.pdf - Accepted Version
Non-alcoholic fatty liver disease (NAFLD) is now the most common liver disease in both adults and children worldwide. A disease spectrum, NAFLD progresses from simple steatosis to steatohepatitis, advanced fibrosis and cirrhosis. An estimated 20-35% of the general population has steatosis and 10% of these will develop the more progressive non-alcoholic steatohepatitis associated with significant increased risk of cardiovascular- and liver-related mortality. Development of NAFLD is strongly linked to components of the metabolic syndrome including obesity, insulin resistance, dyslipidaemia and type 2 diabetes. The recognition that NAFLD is an independent risk factor for cardiovascular disease is a major public health concern. There is tremendous need for a sensitive, non-invasive test for early detection and staging of NAFLD that could also be used to monitor response to treatment. The cellular and molecular aetiology of NAFLD is multi-factorial; genetic polymorphisms influencing NAFLD have been identified and nutrition is a modifiable environmental factor influencing NAFLD progression. Weight loss through diet and exercise is the primary recommendation in the clinical management of NAFLD. The application of systems biology to the identification of NAFLD biomarkers and factors involved in NAFLD progression is an area of promising research.
|Uncontrolled Keywords:||Disease Progression, Fatty Liver, Humans, Metabolic Syndrome X, Obesity, Systems Biology|
|Divisions:||Faculty of Health and Medical Sciences > Nutrition and Metabolism|
|Depositing User:||Christina Daoutis|
|Date Deposited:||15 Oct 2010 16:57|
|Last Modified:||23 Sep 2013 18:38|
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