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Two-Step Synthesis of Aza- and Diazaindoles from Chloroamino-N-heterocycles Using Ethoxyvinylborolane

Whelligan, DK, Thomson, DW, Taylor, D and Hoelder, S (2010) Two-Step Synthesis of Aza- and Diazaindoles from Chloroamino-N-heterocycles Using Ethoxyvinylborolane J Org Chem, 75 (1). 11 - 15. ISSN 0022-3263

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Abstract

An efficient two-step route to a broad range of aza- and diazaindoles was established, starting from chloroamino-N-heterocycles, without the need for protecting groups. The method involves an optimized Suzuki-Miyaura coupling with (2-ethoxyvinyl)borolane followed by acetic acid-catalyzed cyclization.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
AuthorsEmail
Whelligan, DKUNSPECIFIED
Thomson, DWUNSPECIFIED
Taylor, DUNSPECIFIED
Hoelder, SUNSPECIFIED
Date : 1 January 2010
Identification Number : 10.1021/jo902143f
Uncontrolled Keywords : CROSS-COUPLING REACTIONS, SUZUKI-MIYAURA REACTION, HIGHLY-ACTIVE CATALYST, CONVENIENT SYNTHESIS, KINASE INHIBITORS, ARYL CHLORIDES, REACTIVITY, AZAINDOLES, DESIGN, 7-AZAINDOLES
Depositing User : Symplectic Elements
Date Deposited : 02 Mar 2012 14:58
Last Modified : 09 Jun 2014 13:40
URI: http://epubs.surrey.ac.uk/id/eprint/235557

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