Two-Step Synthesis of Aza- and Diazaindoles from Chloroamino-N-heterocycles Using Ethoxyvinylborolane
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Whelligan, DK, Thomson, DW, Taylor, D and Hoelder, S (2010) Two-Step Synthesis of Aza- and Diazaindoles from Chloroamino-N-heterocycles Using Ethoxyvinylborolane The Journal of Organic Chemistry, 75 (1). 11 - 15. ISSN 0022-3263
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Official URL: http://dx.doi.org/10.1021/jo902143f
Abstract
An efficient two-step route to a broad range of aza- and diazaindoles was established, starting from chloroamino-N-heterocycles, without the need for protecting groups. The method involves an optimized Suzuki-Miyaura coupling with (2-ethoxyvinyl)borolane followed by acetic acid-catalyzed cyclization.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CROSS-COUPLING REACTIONS, SUZUKI-MIYAURA REACTION, HIGHLY-ACTIVE CATALYST, CONVENIENT SYNTHESIS, KINASE INHIBITORS, ARYL CHLORIDES, REACTIVITY, AZAINDOLES, DESIGN, 7-AZAINDOLES |
| Divisions: | Faculty of Engineering and Physical Sciences > Chemistry |
| ID Code: | 235557 |
| Deposited By: | Symplectic Elements |
| Deposited On: | 02 Mar 2012 14:58 |
| Last Modified: | 16 Feb 2013 15:34 |
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