Two-Step Synthesis of Aza- and Diazaindoles from Chloroamino-N-heterocycles Using Ethoxyvinylborolane
Whelligan, DK, Thomson, DW, Taylor, D and Hoelder, S (2010) Two-Step Synthesis of Aza- and Diazaindoles from Chloroamino-N-heterocycles Using Ethoxyvinylborolane J Org Chem, 75 (1). 11 - 15. ISSN 0022-3263
Available under License : See the attached licence file.
An efficient two-step route to a broad range of aza- and diazaindoles was established, starting from chloroamino-N-heterocycles, without the need for protecting groups. The method involves an optimized Suzuki-Miyaura coupling with (2-ethoxyvinyl)borolane followed by acetic acid-catalyzed cyclization.
|Divisions :||Faculty of Engineering and Physical Sciences > Chemistry|
|Date :||1 January 2010|
|Uncontrolled Keywords :||CROSS-COUPLING REACTIONS, SUZUKI-MIYAURA REACTION, HIGHLY-ACTIVE CATALYST, CONVENIENT SYNTHESIS, KINASE INHIBITORS, ARYL CHLORIDES, REACTIVITY, AZAINDOLES, DESIGN, 7-AZAINDOLES|
|Depositing User :||Symplectic Elements|
|Date Deposited :||02 Mar 2012 14:58|
|Last Modified :||09 Jun 2014 13:40|
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