Two-Step Synthesis of Aza- and Diazaindoles from Chloroamino-N-heterocycles Using Ethoxyvinylborolane
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Whelligan, DK, Thomson, DW, Taylor, D and Hoelder, S (2010) Two-Step Synthesis of Aza- and Diazaindoles from Chloroamino-N-heterocycles Using Ethoxyvinylborolane J Org Chem, 75 (1). pp. 11-15.
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Official URL: http://dx.doi.org/10.1021/jo902143f
Abstract
An efficient two-step route to a broad range of aza- and diazaindoles was established, starting from chloroamino-N-heterocycles, without the need for protecting groups. The method involves an optimized Suzuki-Miyaura coupling with (2-ethoxyvinyl)borolane followed by acetic acid-catalyzed cyclization.
Item Type: | Article | |||||||||||||||
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Divisions : | Faculty of Engineering and Physical Sciences > Chemistry | |||||||||||||||
Authors : |
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Date : | 1 January 2010 | |||||||||||||||
DOI : | 10.1021/jo902143f | |||||||||||||||
Uncontrolled Keywords : | CROSS-COUPLING REACTIONS, SUZUKI-MIYAURA REACTION, HIGHLY-ACTIVE CATALYST, CONVENIENT SYNTHESIS, KINASE INHIBITORS, ARYL CHLORIDES, REACTIVITY, AZAINDOLES, DESIGN, 7-AZAINDOLES | |||||||||||||||
Depositing User : | Symplectic Elements | |||||||||||||||
Date Deposited : | 02 Mar 2012 14:58 | |||||||||||||||
Last Modified : | 31 Oct 2017 14:27 | |||||||||||||||
URI: | http://epubs.surrey.ac.uk/id/eprint/235557 |
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