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Two-Step Synthesis of Aza- and Diazaindoles from Chloroamino-N-heterocycles Using Ethoxyvinylborolane

Whelligan, DK, Thomson, DW, Taylor, D and Hoelder, S (2010) Two-Step Synthesis of Aza- and Diazaindoles from Chloroamino-N-heterocycles Using Ethoxyvinylborolane J Org Chem, 75 (1). 11 - 15. ISSN 0022-3263

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Abstract

An efficient two-step route to a broad range of aza- and diazaindoles was established, starting from chloroamino-N-heterocycles, without the need for protecting groups. The method involves an optimized Suzuki-Miyaura coupling with (2-ethoxyvinyl)borolane followed by acetic acid-catalyzed cyclization.

Item Type: Article
Uncontrolled Keywords: CROSS-COUPLING REACTIONS, SUZUKI-MIYAURA REACTION, HIGHLY-ACTIVE CATALYST, CONVENIENT SYNTHESIS, KINASE INHIBITORS, ARYL CHLORIDES, REACTIVITY, AZAINDOLES, DESIGN, 7-AZAINDOLES
Divisions: Faculty of Engineering and Physical Sciences > Chemistry
Depositing User: Symplectic Elements
Date Deposited: 02 Mar 2012 14:58
Last Modified: 09 Jun 2014 13:40
URI: http://epubs.surrey.ac.uk/id/eprint/235557

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