Two-Step Synthesis of Aza- and Diazaindoles from Chloroamino-N-heterocycles Using Ethoxyvinylborolane

Whelligan, DK, Thomson, DW, Taylor, D and Hoelder, S (2010) Two-Step Synthesis of Aza- and Diazaindoles from Chloroamino-N-heterocycles Using Ethoxyvinylborolane J Org Chem, 75 (1). pp. 11-15.

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Abstract

An efficient two-step route to a broad range of aza- and diazaindoles was established, starting from chloroamino-N-heterocycles, without the need for protecting groups. The method involves an optimized Suzuki-Miyaura coupling with (2-ethoxyvinyl)borolane followed by acetic acid-catalyzed cyclization.

Item Type:	Article
Divisions :	Faculty of Engineering and Physical Sciences > Chemistry
Authors :	Name Email ORCID Whelligan, DK Thomson, DW Taylor, D Hoelder, S
Date :	1 January 2010
DOI :	10.1021/jo902143f
Uncontrolled Keywords :	CROSS-COUPLING REACTIONS, SUZUKI-MIYAURA REACTION, HIGHLY-ACTIVE CATALYST, CONVENIENT SYNTHESIS, KINASE INHIBITORS, ARYL CHLORIDES, REACTIVITY, AZAINDOLES, DESIGN, 7-AZAINDOLES
Depositing User :	Symplectic Elements
Date Deposited :	02 Mar 2012 14:58
Last Modified :	31 Oct 2017 14:27
URI:	http://epubs.surrey.ac.uk/id/eprint/235557

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