Two-Step Synthesis of Aza- and Diazaindoles from Chloroamino-N-heterocycles Using Ethoxyvinylborolane
Whelligan, DK, Thomson, DW, Taylor, D and Hoelder, S (2010) Two-Step Synthesis of Aza- and Diazaindoles from Chloroamino-N-heterocycles Using Ethoxyvinylborolane The Journal of Organic Chemistry, 75 (1). 11 - 15. ISSN 0022-3263
Available under License : See the attached licence file.
Official URL: http://dx.doi.org/10.1021/jo902143f
An efficient two-step route to a broad range of aza- and diazaindoles was established, starting from chloroamino-N-heterocycles, without the need for protecting groups. The method involves an optimized Suzuki-Miyaura coupling with (2-ethoxyvinyl)borolane followed by acetic acid-catalyzed cyclization.
|Uncontrolled Keywords:||CROSS-COUPLING REACTIONS, SUZUKI-MIYAURA REACTION, HIGHLY-ACTIVE CATALYST, CONVENIENT SYNTHESIS, KINASE INHIBITORS, ARYL CHLORIDES, REACTIVITY, AZAINDOLES, DESIGN, 7-AZAINDOLES|
|Divisions:||Faculty of Engineering and Physical Sciences > Chemistry|
|Deposited By:||Symplectic Elements|
|Deposited On:||02 Mar 2012 14:58|
|Last Modified:||16 Feb 2013 15:34|
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