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Miscibility Gap in the Microbial Fitness Landscape

Braun, F N, Paulsen, S, Sear, RP and Warren, P B (2005) Miscibility Gap in the Microbial Fitness Landscape Physical Review Letters, 94 (17).


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It is shown from molecular statistical considerations that a demixing instability exists in the moment space of a microbial protein expression profile. Although avoidance of demixing is generally requisite for biological function, a comparison with proteomic and genomic data suggests that many microbes lie close to the onset of this instability. Over evolutionary time scales, straying too close or into the immiscible domain may be associated with intracellular compartmentalization.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Physics
Authors :
Braun, F N
Paulsen, S
Warren, P B
Date : 1 January 2005
DOI : 10.1103/PhysRevLett.94.178105
Additional Information : Published in Physical Review Letters, Vol. 94, Iss. 17. Copyright 2005 American Physical Society. Click here to access the journal's website.
Depositing User : Mr Adam Field
Date Deposited : 27 May 2010 14:07
Last Modified : 16 Jan 2019 16:18

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