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Post-transcriptional gene regulation: from genome-wide studies to principles.

Halbeisen, RE, Galgano, A, Scherrer, T and Gerber, AP (2008) Post-transcriptional gene regulation: from genome-wide studies to principles. Cell Mol Life Sci, 65 (5). pp. 798-813.

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Abstract

Post-transcriptional regulation of gene expression plays important roles in diverse cellular processes such as development, metabolism and cancer progression. Whereas many classical studies explored the mechanistics and physiological impact on specific mRNA substrates, the recent development of genome-wide analysis tools enables the study of post-transcriptional gene regulation on a global scale. Importantly, these studies revealed distinct programs of RNA regulation, suggesting a complex and versatile post-transcriptional regulatory network. This network is controlled by specific RNA-binding proteins and/or non-coding RNAs, which bind to specific sequence or structural elements in the RNAs and thereby regulate subsets of mRNAs that partly encode functionally related proteins. It will be a future challenge to link the spectra of targets for RNA-binding proteins to post-transcriptional regulatory programs and to reveal its physiological implications.

Item Type: Article
Authors :
NameEmailORCID
Halbeisen, REUNSPECIFIEDUNSPECIFIED
Galgano, AUNSPECIFIEDUNSPECIFIED
Scherrer, TUNSPECIFIEDUNSPECIFIED
Gerber, APUNSPECIFIEDUNSPECIFIED
Date : March 2008
Identification Number : 10.1007/s00018-007-7447-6
Uncontrolled Keywords : Gene Expression Regulation, Genome, Human, Humans, RNA Processing, Post-Transcriptional, Regulatory Elements, Transcriptional, Transcription, Genetic
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 28 Mar 2017 14:39
Last Modified : 31 Oct 2017 14:26
URI: http://epubs.surrey.ac.uk/id/eprint/211750

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