University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Post-transcriptional gene regulation: from genome-wide studies to principles.

Halbeisen, RE, Galgano, A, Scherrer, T and Gerber, AP (2008) Post-transcriptional gene regulation: from genome-wide studies to principles. Cell Mol Life Sci, 65 (5). pp. 798-813.

[img] Text
Halbeisen et al. 2008 CMLS.pdf
Restricted to Repository staff only
Available under License : See the attached licence file.

Download (651kB)
[img] Text (licence)
Restricted to Repository staff only

Download (33kB)


Post-transcriptional regulation of gene expression plays important roles in diverse cellular processes such as development, metabolism and cancer progression. Whereas many classical studies explored the mechanistics and physiological impact on specific mRNA substrates, the recent development of genome-wide analysis tools enables the study of post-transcriptional gene regulation on a global scale. Importantly, these studies revealed distinct programs of RNA regulation, suggesting a complex and versatile post-transcriptional regulatory network. This network is controlled by specific RNA-binding proteins and/or non-coding RNAs, which bind to specific sequence or structural elements in the RNAs and thereby regulate subsets of mRNAs that partly encode functionally related proteins. It will be a future challenge to link the spectra of targets for RNA-binding proteins to post-transcriptional regulatory programs and to reveal its physiological implications.

Item Type: Article
Authors :
Halbeisen, RE
Galgano, A
Scherrer, T
Gerber, AP
Date : March 2008
DOI : 10.1007/s00018-007-7447-6
Uncontrolled Keywords : Gene Expression Regulation, Genome, Human, Humans, RNA Processing, Post-Transcriptional, Regulatory Elements, Transcriptional, Transcription, Genetic
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 28 Mar 2017 14:39
Last Modified : 31 Oct 2017 14:26

Actions (login required)

View Item View Item


Downloads per month over past year

Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800