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Defining potentially conserved RNA regulons of homologous zinc-finger RNA-binding proteins.

Scherrer, T, Femmer, C, Schiess, R, Aebersold, R and Gerber, AP (2011) Defining potentially conserved RNA regulons of homologous zinc-finger RNA-binding proteins. Genome Biology, 12 (1). R3 - ?. ISSN 1474-760X

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Abstract

Glucose inhibition of gluconeogenic growth suppressor 2 protein (Gis2p) and zinc-finger protein 9 (ZNF9) are conserved yeast and human zinc-finger proteins. The function of yeast Gis2p is unknown, but human ZNF9 has been reported to bind nucleic acids, and mutations in the ZNF9 gene cause the neuromuscular disease myotonic dystrophy type 2. To explore the impact of these proteins on RNA regulation, we undertook a systematic analysis of the RNA targets and of the global implications for gene expression.

Item Type: Article
Additional Information: Subject to license at: http://www.biomedcentral.com/about/license
Uncontrolled Keywords: Amino Acid Sequence, Cell Proliferation, Cell Size, Codon, Initiator, Conserved Sequence, Gene Expression Profiling, Gene Expression Regulation, Humans, Molecular Sequence Data, Open Reading Frames, Phenotype, Proteome, RNA, Messenger, RNA-Binding Proteins, Regulon, Repetitive Sequences, Nucleic Acid, Saccharomyces cerevisiae Proteins, Sequence Alignment, Sequence Homology, Amino Acid, Transcriptome, Zinc Fingers
Divisions: Faculty of Health and Medical Sciences > Microbial and Cellular Sciences
Depositing User: Symplectic Elements
Date Deposited: 04 May 2012 11:29
Last Modified: 23 Sep 2013 19:13
URI: http://epubs.surrey.ac.uk/id/eprint/211742

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