Defining potentially conserved RNA regulons of homologous zinc-finger RNA-binding proteins.
Scherrer, T, Femmer, C, Schiess, R, Aebersold, R and Gerber, AP (2011) Defining potentially conserved RNA regulons of homologous zinc-finger RNA-binding proteins. Genome Biology, 12 (1). R3 - ?. ISSN 1474-760X
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Glucose inhibition of gluconeogenic growth suppressor 2 protein (Gis2p) and zinc-finger protein 9 (ZNF9) are conserved yeast and human zinc-finger proteins. The function of yeast Gis2p is unknown, but human ZNF9 has been reported to bind nucleic acids, and mutations in the ZNF9 gene cause the neuromuscular disease myotonic dystrophy type 2. To explore the impact of these proteins on RNA regulation, we undertook a systematic analysis of the RNA targets and of the global implications for gene expression.
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|Uncontrolled Keywords:||Amino Acid Sequence, Cell Proliferation, Cell Size, Codon, Initiator, Conserved Sequence, Gene Expression Profiling, Gene Expression Regulation, Humans, Molecular Sequence Data, Open Reading Frames, Phenotype, Proteome, RNA, Messenger, RNA-Binding Proteins, Regulon, Repetitive Sequences, Nucleic Acid, Saccharomyces cerevisiae Proteins, Sequence Alignment, Sequence Homology, Amino Acid, Transcriptome, Zinc Fingers|
|Divisions:||Faculty of Health and Medical Sciences > Microbial and Cellular Sciences|
|Deposited By:||Symplectic Elements|
|Deposited On:||04 May 2012 12:29|
|Last Modified:||25 May 2013 14:45|
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