University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Relationship between melatonin rhythms and visual loss in the blind

Lockley, SW, Skene, DJ, Arendt, J, Tabandeh, H, Bird, AC and Defrance, R (1997) Relationship between melatonin rhythms and visual loss in the blind J CLIN ENDOCR METAB, 82 (11). 3763 - 3770. ISSN 0021-972X

[img]
Preview
PDF
Lockley JCEM 1997.pdf
Available under License : See the attached licence file.

Download (354Kb)
[img]
Preview
PDF (licence)
SRI_deposit_agreement.pdf

Download (32Kb)

Abstract

Melatonin rhythms were assessed in 49 registered blind individuals by measurement of the urinary metabolite of melatonin, 6-sulfatoxymelatonin (aMT6s). Subjects had different causes of visual loss and were classified as having light perception or better (LP; n 5 19) or having no perception of light (NPL; n 5 30). Subjects collected four-hourly urine samples (eight-hourly overnight) for 48 h at weekly intervals for 3–5 weeks. The majority of LP subjects (14 of 19) had normally entrained aMT6s rhythms (mean acrophase range, 2.4–6.2 h), 4 were abnormally entrained to 24 h (mean acrophase range, 8.9–1.0 h), and 1 was unclassified. Conversely, mostNPLsubjects had abnormal rhythms (23 of 30), the incidence of which was greater in uni- and bilaterally enucleated subjects. The majority of NPL subjects (17 of 30) had free-running aMT6s rhythms (period range, 24.13– 24.79 h), 5 were abnormally entrained to 24 h (acrophase range, 7.2–20.6 h), and 1 was unclassified. Output (micrograms of aMT6s per 24 h) and amplitude (micrograms per h) of aMT6s production did not vary between LP and NPL subjects (mean 24-h output 6 SD, 12.7 6 7.5 and 9.4 6 6.4 mg aMT6s/24 h, respectively; mean amplitude 6 SD, 0.660.4 and 0.560.3 mg/h, respectively). These results indicate that a higher proportion of NPL subjects have abnormal melatonin rhythms compared to those with LP. (J Clin Endocrinol Metab 82: 3763–3770, 1997)

Item Type: Article
Additional Information: Original available at: http://jcem.endojournals.org/content/82/11/3763.full
Uncontrolled Keywords: BRIGHT LIGHT, CIRCADIAN-RHYTHMS, PLASMA MELATONIN, PHASE-SHIFTS, JET-LAG, SLEEP, 6-SULPHATOXYMELATONIN, NIGHT, 6-SULFATOXYMELATONIN, SUPPRESSION
Divisions: Faculty of Health and Medical Sciences > Biochemistry and Physiology
Depositing User: Symplectic Elements
Date Deposited: 09 Mar 2012 10:55
Last Modified: 23 Sep 2013 19:12
URI: http://epubs.surrey.ac.uk/id/eprint/207054

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800