The physiological period length of the human circadian clock in vivo is directly proportional to period in human fibroblasts.

Pagani, L, Semenova, EA, Moriggi, E, Revell, VL, Hack, LM, Lockley, SW, Arendt, J, Skene, DJ, Meier, F and Izakovic, J (2010) The physiological period length of the human circadian clock in vivo is directly proportional to period in human fibroblasts. PLoS One, 5 (10).

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Abstract

Diurnal behavior in humans is governed by the period length of a circadian clock in the suprachiasmatic nuclei of the brain hypothalamus. Nevertheless, the cell-intrinsic mechanism of this clock is present in most cells of the body. We have shown previously that for individuals of extreme chronotype ("larks" and "owls"), clock properties measured in human fibroblasts correlated with extreme diurnal behavior.

Item Type:	Article
Divisions :	Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Biochemical Sciences
Authors :	Name Email ORCID Pagani, L Semenova, EA Moriggi, E Revell, VL Hack, LM Lockley, SW Arendt, J Skene, DJ Meier, F Izakovic, J
Date :	2010
DOI :	10.1371/journal.pone.0013376
Uncontrolled Keywords :	Circadian Clocks, Fibroblasts, Humans
Additional Information :	Copyright: © 2010 Pagani et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Depositing User :	Symplectic Elements
Date Deposited :	29 Feb 2012 14:25
Last Modified :	31 Oct 2017 14:25
URI:	http://epubs.surrey.ac.uk/id/eprint/207031

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