The physiological period length of the human circadian clock in vivo is directly proportional to period in human fibroblasts.
Pagani, L, Semenova, EA, Moriggi, E, Revell, VL, Hack, LM, Lockley, SW, Arendt, J, Skene, DJ, Meier, F and Izakovic, J (2010) The physiological period length of the human circadian clock in vivo is directly proportional to period in human fibroblasts. PLoS One, 5 (10).
Pagani PLoS ONE.pdf - Version of Record
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Diurnal behavior in humans is governed by the period length of a circadian clock in the suprachiasmatic nuclei of the brain hypothalamus. Nevertheless, the cell-intrinsic mechanism of this clock is present in most cells of the body. We have shown previously that for individuals of extreme chronotype ("larks" and "owls"), clock properties measured in human fibroblasts correlated with extreme diurnal behavior.
|Divisions :||Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Biochemical Sciences|
|Identification Number :||https://doi.org/10.1371/journal.pone.0013376|
|Uncontrolled Keywords :||Circadian Clocks, Fibroblasts, Humans|
|Additional Information :||Copyright: © 2010 Pagani et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
|Depositing User :||Symplectic Elements|
|Date Deposited :||29 Feb 2012 14:25|
|Last Modified :||23 Sep 2013 19:12|
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