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Metabolic and evolutionary insights into the closely-related species Streptomyces coelicolor and Streptomyces lividans deduced from high-resolution comparative genomic hybridization.

Lewis, RA, Laing, E, Allenby, N, Bucca, G, Brenner, V, Harrison, M, Kierzek, AM and Smith, CP (2010) Metabolic and evolutionary insights into the closely-related species Streptomyces coelicolor and Streptomyces lividans deduced from high-resolution comparative genomic hybridization. BMC Genomics, 11. 682 - ?. ISSN 1471-2164

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Abstract

Whilst being closely related to the model actinomycete Streptomyces coelicolor A3(2), S. lividans 66 differs from it in several significant and phenotypically observable ways, including antibiotic production. Previous comparative gene hybridization studies investigating such differences have used low-density (one probe per gene) PCR-based spotted arrays. Here we use new experimentally optimised 104,000 × 60-mer probe arrays to characterize in detail the genomic differences between wild-type S. lividans 66, a derivative industrial strain, TK24, and S. coelicolor M145.

Item Type: Article
Additional Information: © 2010 Lewis et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords: Anthraquinones, Base Composition, Base Sequence, Chromosomes, Bacterial, Comparative Genomic Hybridization, DNA Probes, DNA, Intergenic, Evolution, Molecular, Genes, Bacterial, Genetic Variation, Genomics, Molecular Sequence Data, Multigene Family, Oligonucleotide Array Sequence Analysis, Phylogeny, S-Adenosylmethionine, Sequence Alignment, Species Specificity, Streptomyces coelicolor, Streptomyces lividans
Divisions: Faculty of Health and Medical Sciences > Microbial and Cellular Sciences
Depositing User: Symplectic Elements
Date Deposited: 28 Mar 2012 11:30
Last Modified: 23 Sep 2013 19:11
URI: http://epubs.surrey.ac.uk/id/eprint/203299

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