ESTs and SNPs: What large scale sequencing projects can tell us about ADME

Plant, Nick (2006) ESTs and SNPs: What large scale sequencing projects can tell us about ADME Xenobiotica, 36 (10-11). pp. 10-11.

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Abstract

To date over 800 complete genomes have been sequenced, with many more partially complete. Coupled with the large amount of mRNA transcript sequence data being produced from expression studies, there is now a daunting amount of information available to the research scientist. This review examines how this information may be best used, focusing on examples from sequences encoding absorption, distribution, metabolism and excretion (ADME)-related proteins in particular. Through the use of phylogenetic, splice variant and single nucleotide polymorphism (SNP) analysis, the review examines not only how insights into species-specific responses to drug exposure may be gained, but also how best to utilize this information to predict both individual human responses and the impact of population variance in response.

Item Type:	Article
Divisions :	Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Biochemical Sciences
Authors :	Authors Email ORCID Plant, Nick n.plant@surrey.ac.uk UNSPECIFIED
Date :	1 October 2006
Identification Number :	10.1080/00498250600861603
Additional Information :	This is the author's pre-print published as: ESTs and SNPs: What large scale sequencing projects can tell us about ADME. Xenobiotica, Volume 36, Numbers 10-11, October 2006, pp. 860-876(17).
Depositing User :	Mr Adam Field
Date Deposited :	27 May 2010 14:46
Last Modified :	23 Sep 2013 18:36
URI:	http://epubs.surrey.ac.uk/id/eprint/1951

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