ESTs and SNPs: What large scale sequencing projects can tell us about ADME
Plant, Nick (2006) ESTs and SNPs: What large scale sequencing projects can tell us about ADME Xenobiotica, 36 (10-11). pp. 10-11.
To date over 800 complete genomes have been sequenced, with many more partially complete. Coupled with the large amount of mRNA transcript sequence data being produced from expression studies, there is now a daunting amount of information available to the research scientist. This review examines how this information may be best used, focusing on examples from sequences encoding absorption, distribution, metabolism and excretion (ADME)-related proteins in particular. Through the use of phylogenetic, splice variant and single nucleotide polymorphism (SNP) analysis, the review examines not only how insights into species-specific responses to drug exposure may be gained, but also how best to utilize this information to predict both individual human responses and the impact of population variance in response.
|Divisions :||Faculty of Health and Medical Sciences > Biochemistry and Physiology|
|Date :||1 October 2006|
|Identification Number :||10.1080/00498250600861603|
|Additional Information :||This is the author's pre-print published as: ESTs and SNPs: What large scale sequencing projects can tell us about ADME. Xenobiotica, Volume 36, Numbers 10-11, October 2006, pp. 860-876(17).|
|Depositing User :||Mr Adam Field|
|Date Deposited :||27 May 2010 14:46|
|Last Modified :||23 Sep 2013 18:36|
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