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HOX transcription factors are potential therapeutic targets in non-small cell lung cancer

Plowright, L, Harrington, K, Pandha, HS and Morgan, R (2009) HOX transcription factors are potential therapeutic targets in non-small cell lung cancer British Journal of Cancer.

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Abstract

The HOX genes are a family of homeodomain-containing transcription factors that determine the identity of cells and tissues during embryonic development. They are also known to behave as oncogenes in some haematological malignancies. In this study we show that the expression of many of the HOX genes is highly elevated in primary non-small cell lung cancers and in the derived cell lines A549 and H23. Furthermore, blocking the activity of HOX proteins by interfering with their binding to the PBX co-factor causes these cells to undergo apoptosis in vitro and reduces the growth of A549 tumours in vivo. These findings suggest that the interaction between HOX and PBX proteins is a potential therapeutic target in non-small cell lung cancer.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Microbial and Cellular Sciences
Authors :
NameEmailORCID
Plowright, Llplowrig@sgul.ac.ukUNSPECIFIED
Harrington, KKevin.Harrington@icr.ac.ukUNSPECIFIED
Pandha, HSh.pandha@surrey.ac.ukUNSPECIFIED
Morgan, Rr.morgan@surrey.ac.ukUNSPECIFIED
Date : 2009
Depositing User : Richard Morgan
Date Deposited : 28 Mar 2017 15:06
Last Modified : 31 Oct 2017 14:24
URI: http://epubs.surrey.ac.uk/id/eprint/192989

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