Genetic predisposition influences plasma lipids of participants on habitual diet, but not the response to reductions in dietary intake of saturated fatty acids
Walker, CG, Loos, RJF, Olson, AD, Frost, GS, Griffin, BA, Lovegrove, JA, Sanders, TAB, Jebb, SA and RISCK Study Grp, (2011) Genetic predisposition influences plasma lipids of participants on habitual diet, but not the response to reductions in dietary intake of saturated fatty acids ATHEROSCLEROSIS, 215 (2). pp. 421-427.
Objective SNPs identified from genome-wide association studies associate with lipid risk markers of cardiovascular disease. This study investigated whether these SNPs altered the plasma lipid response to diet in the ‘RISCK’ study cohort. Methods Participants (n = 490) from a dietary intervention to lower saturated fat by replacement with carbohydrate or monounsaturated fat, were genotyped for 39 lipid-associated SNPs. The association of each individual SNP, and of the SNPs combined (using genetic predisposition scores), with plasma lipid concentrations was assessed at baseline, and on change in response to 24 weeks on diets. Results The associations between SNPs and lipid concentrations were directionally consistent with previous findings. The genetic predisposition scores were associated with higher baseline concentrations of plasma total (P = 0.02) and LDL (P = 0.002) cholesterol, triglycerides (P = 0.001) and apolipoprotein B (P = 0.004), and with lower baseline concentrations of HDL cholesterol (P < 0.001) and apolipoprotein A-I (P < 0.001). None of the SNPs showed significant association with the reduction of plasma lipids in response to the dietary interventions and there was no evidence of diet-gene interactions. Conclusion Results from this exploratory study have shown that increased genetic predisposition was associated with an unfavourable plasma lipid profile at baseline, but did not influence the improvement in lipid profiles by the low-saturated-fat diets.
|Divisions :||Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Nutritional Sciences|
|Date :||April 2011|
|Identification Number :||10.1016/j.atherosclerosis.2010.12.039|
|Uncontrolled Keywords :||Dietary saturated fat, Plasma lipids, SNP, Genetic predisposition score, Lipoprotein, Gene-diet-interaction, DENSITY-LIPOPROTEIN CHOLESTEROL, GENOME-WIDE ASSOCIATION, CARDIOVASCULAR-DISEASE, INSULIN SENSITIVITY, HDL-CHOLESTEROL, BLOOD-LIPIDS, LOCI, CARBOHYDRATE, METAANALYSIS, VARIANTS|
|Additional Information :||Copyright 2011 Elsevier. NOTICE: this is the author’s version of a work that was accepted for publication in Atherosclerosis. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Atherosclerosis, 215(2), April 2011, DOI: 10.1016/j.atherosclerosis.2010.12.039|
|Depositing User :||Symplectic Elements|
|Date Deposited :||07 Mar 2012 14:21|
|Last Modified :||23 Sep 2013 19:09|
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