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Reducing coronary risk by raising HDL-cholesterol: risk modelling the addition of nicotinic acid to existing therapy.

Belsey, J, de Lusignan, S, van Vlymen, J, Chan, T and Hague, N (2008) Reducing coronary risk by raising HDL-cholesterol: risk modelling the addition of nicotinic acid to existing therapy. Curr Med Res Opin, 24 (9). pp. 2703-2709.

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Abstract

Reduction in total cholesterol (TC) and LDL-cholesterol (LDL-C) forms one of the principal objectives of most cardiovascular secondary prevention strategies. Many patients being treated with statins, however, have significant residual dyslipidaemia, with many having suboptimal HDL-cholesterol (HDL-C) levels. The addition of nicotinic acid to a statin has been shown to improve this profile, although clinical outcome evidence is currently lacking. This study set out to model the impact of nicotinic acid therapy on cardiovascular risk in these patients, based on Framingham risk assessments on a cohort of patients drawn from UK general practitioner records.

Item Type: Article
Authors :
AuthorsEmailORCID
Belsey, JUNSPECIFIEDUNSPECIFIED
de Lusignan, SUNSPECIFIEDUNSPECIFIED
van Vlymen, JUNSPECIFIEDUNSPECIFIED
Chan, TUNSPECIFIEDUNSPECIFIED
Hague, NUNSPECIFIEDUNSPECIFIED
Date : September 2008
Identification Number : https://doi.org/10.1185/03007990802374633
Uncontrolled Keywords : Cholesterol, HDL, Coronary Disease, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Niacin, Risk Factors
Depositing User : Symplectic Elements
Date Deposited : 28 Mar 2017 15:05
Last Modified : 28 Mar 2017 15:05
URI: http://epubs.surrey.ac.uk/id/eprint/189411

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