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Acorn: a grid computing system for constraint based modeling and visualization of the genome scale metabolic reaction networks via a web interface.

Sroka, J, Bieniasz-Krzywiec, L, Gwóźdź, S, Leniowski, D, Lącki, J, Markowski, M, Avignone-Rossa, C, Bushell, ME, McFadden, J and Kierzek, AM (2011) Acorn: a grid computing system for constraint based modeling and visualization of the genome scale metabolic reaction networks via a web interface. BMC Bioinformatics, 12 (196). ? - ?. ISSN 1471-2105

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Abstract

Constraint-based approaches facilitate the prediction of cellular metabolic capabilities, based, in turn on predictions of the repertoire of enzymes encoded in the genome. Recently, genome annotations have been used to reconstruct genome scale metabolic reaction networks for numerous species, including Homo sapiens, which allow simulations that provide valuable insights into topics, including predictions of gene essentiality of pathogens, interpretation of genetic polymorphism in metabolic disease syndromes and suggestions for novel approaches to microbial metabolic engineering. These constraint-based simulations are being integrated with the functional genomics portals, an activity that requires efficient implementation of the constraint-based simulations in the web-based environment.

Item Type: Article
Additional Information: This article (© 2011 Sroka et al; licensee BioMed Central Ltd) was distributed with permission from the publisher under the following licence: http://www.biomedcentral.com/about/license
Divisions: Faculty of Health and Medical Sciences > Microbial and Cellular Sciences
Depositing User: Symplectic Elements
Date Deposited: 28 Mar 2012 13:36
Last Modified: 23 Sep 2013 19:07
URI: http://epubs.surrey.ac.uk/id/eprint/185976

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