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Selenoproteins and human health: Insights from epidemiological data

Rayman, MP (2009) Selenoproteins and human health: Insights from epidemiological data BBA-GEN SUBJECTS, 1790 (11). 1533 - 1540. ISSN 0304-4165

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Abstract

Knowledge of the plasma selenium levels associated with optimised concentration or activity of specific selenoproteins can provide considerable insights from epidemiological data on the possible involvement of those selenoproteins in health, most notably with respect to cancer. For cohort studies, if selenoproteins such as glutathione peroxidase and selenoprotein P are relevant to cancer, one might only expect to see an effect on risk when the concentrations in the cohort range from below, to above, the level needed to optimise the activity or concentration of these enzymes. Similarly, trials would only show a beneficial effect of supplementation if selenium status were raised from below, to above, the optimal concentration for the selenoproteins likely to be implicated in cancer risk, as occurred in the NPC trial but not in SELECT. The most powerful evidence for the involvement of selenoproteins in human health comes from epidemiological studies that have related single nucleotide polymorphisms in selenoproteins to disease risk. The totality of the evidence currently implicates GPx1, GPx4, SEPS1, Sep15, SEPP1 and TXNRD1 in conditions such as cardiovascular disease, pre-eclampsia and cancer. Future studies therefore need to determine not only selenium status, but genotype, both in selenoproteins and related pathways, when investigating the relationship of selenium with disease risk.

Item Type: Article
Additional Information: Copyright © 2009 Elsevier B.V. All rights reserved.NOTICE: this is the author’s version of a work that was accepted for publication in Biochimica et Biophysica Acta (BBA) - General Subjects. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Biochimica et Biophysica Acta (BBA) - General Subjects, 1790(11), November 2009, DOI: 10.1016/j.bbagen.2009.03.014
Uncontrolled Keywords: Selenoprotein, Selenium, Epidemiology, Single nucleotide polymorphism, Health, Cancer, BREAST-CANCER RISK, SINGLE-NUCLEOTIDE POLYMORPHISM, MANGANESE SUPEROXIDE-DISMUTASE, GPX1 PRO198LEU POLYMORPHISM, PROSTATE-CANCER, SELENIUM SUPPLEMENTATION, LUNG-CANCER, NO ASSOCIATION, 3'-UNTRANSLATED REGION, NUTRITIONAL PREVENTION
Divisions: Faculty of Health and Medical Sciences > Nutrition and Metabolism
Depositing User: Symplectic Elements
Date Deposited: 07 Mar 2012 14:37
Last Modified: 23 Sep 2013 19:06
URI: http://epubs.surrey.ac.uk/id/eprint/184927

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